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This is a list of singles that peaked in the Top 10 of the Billboard Hot 100 during 2006.
Chris Brown scored four top ten hits during the year with "Run It!", "Yo (Excuse Me Miss)", "Say Goodbye", and "Shortie Like Mine", the most among all other artists.
– indicates single's top 10 entry was also its Hot 100 debut
– indicates Best performing song of the year| Top ten entry date | Single | Artist(s) | Peak | Peak date | Weeks in top ten |
|---|---|---|---|---|---|
| Singles from 2005 | |||||
| November 26 | "Laffy Taffy" | D4L | 1 | January 14 | 11 |
| December 24 | "Grillz" | Nelly featuring Paul Wall and Ali & Gipp | 1 | January 21 | 13 |
| December 31 | "Check on It" (#10) | Beyoncé featuring Bun B and Slim Thug | 1 | February 4 | 14 |
| "There It Go (The Whistle Song)" | Juelz Santana | 6 | January 28 | 5 | |
| Singles from 2006 | |||||
| January 14 | "Dance, Dance" | Fall Out Boy | 9 | January 14 | 1 |
| January 21 | "Dirty Little Secret" | The All-American Rejects | 9 | January 21 | 3 |
| January 28 | "Be Without You" | Mary J. Blige | 3 | February 11 | 14 |
| February 4 | "You're Beautiful" (#4) | James Blunt | 1 | March 11 | 15 |
| February 11 | "Breaking Free" | Zac Efron, Drew Seeley and Vanessa Anne Hudgens | 4 | February 11 | 1 |
| "So Sick" | Ne-Yo | 1 | March 18 | 11 | |
| "Unpredictable" | Jamie Foxx featuring Ludacris | 8 | February 11 | 3 | |
| "Unwritten" (#6) | Natasha Bedingfield | 5 | April 29 | 13 | |
| February 18 | "I'm 'n Luv (Wit a Stripper)" | T-Pain featuring Mike Jones | 5 | February 18 | 9 |
| "Shake That" | Eminem featuring Nate Dogg | 6 | February 25 | 3 | |
| "Yo (Excuse Me Miss)" | Chris Brown | 7 | February 18 | 8 | |
| February 25 | "Temperature" (#2) | Sean Paul | 1 | April 1 | 17 |
| March 11 | "Everytime We Touch" | Cascada | 10 | March 11 | 1 |
| March 18 | "Lean wit It, Rock wit It" | Dem Franchize Boyz featuring Lil Peanut and Charlay | 7 | April 1 | 8 |
| March 25 | "Bad Day" (#1) | Daniel Powter | 1 | April 8 | 14 |
| April 8 | "Ms. New Booty" | Bubba Sparxxx featuring Ying Yang Twins and Mr. Collipark | 7 | May 13 | 6 |
| April 15 | "What You Know" | T.I. | 3 | April 22 | 8 |
| April 22 | "What Hurts the Most" | Rascal Flatts | 6 | April 29 | 2 |
| April 29 | "Control Myself" | LL Cool J featuring Jennifer Lopez | 4 | April 29 | 2 |
| "Dani California" | Red Hot Chili Peppers | 6 | May 27 | 7 | |
| May 6 | "Ridin'" (#8) | Chamillionaire featuring Krayzie Bone | 1 | June 3 | 12 |
| May 13 | "SOS" | Rihanna | 1 | May 13 | 6 |
| "What's Left of Me" | Nick Lachey | 6 | May 13 | 3 | |
| May 20 | "Over My Head (Cable Car)" | The Fray | 8 | June 3 | 8 |
| "Where'd You Go" | Fort Minor featuring Holly Brook and Jonah Matranga | 4 | June 10 | 6 | |
| May 27 | "Snap Yo Fingers" | Lil Jon featuring E-40 and Sean Paul of the YoungBloodZ | 7 | May 27 | 9 |
| June 3 | "Promiscuous" (#3) | Nelly Furtado featuring Timbaland | 1 | July 8 | 17 |
| June 10 | "Hips Don't Lie" (#5) | Shakira featuring Wyclef Jean | 1 | June 17 | 10 |
| "Me & U" | Cassie | 3 | July 22 | 15 | |
| June 17 | "It's Goin' Down" | Yung Joc featuring Nitti | 3 | June 24 | 10 |
| "Unfaithful" | Rihanna | 6 | July 22 | 8 | |
| July 1 | "Do I Make You Proud" | Taylor Hicks | 1 | July 1 | 2 |
| "Crazy" (#7) | Gnarls Barkley | 2 | July 22 | 14 | |
| "Life Is a Highway" | Rascal Flatts | 7 | July 1 | 2 | |
| July 8 | "Ain't No Other Man" | Christina Aguilera | 6 | July 15 | 9 |
| July 15 | "So What" | Field Mob featuring Ciara | 10 | July 15 | 1 |
| July 29 | "Buttons" | The Pussycat Dolls featuring Snoop Dogg | 3 | September 23 | 11 |
| August 12 | "Déjà Vu" | Beyoncé featuring Jay-Z | 4 | August 12 | 2 |
| "London Bridge" | Fergie | 1 | August 19 | 10 | |
| August 19 | "I Write Sins Not Tragedies" | Panic! at the Disco | 7 | August 26 | 3 |
| "(When You Gonna) Give It up to Me" | Sean Paul featuring Keyshia Cole | 3 | September 9 | 6 | |
| August 26 | "Sexy Love" | Ne-Yo | 7 | September 23 | 5 |
| "Shoulder Lean" | Young Dro featuring T.I. | 10 | August 26 | 1 | |
| September 2 | "Get Up" | Ciara featuring Chamillionaire | 7 | September 2 | 1 |
| September 9 | "Call Me When You're Sober" | Evanescence | 10 | September 9 | 1 |
| "SexyBack" (#9) | Justin Timberlake | 1 | September 9 | 12 | |
| "Show Stopper" | Danity Kane featuring Yung Joc | 8 | September 9 | 1 | |
| September 16 | "Chasing Cars" | Snow Patrol | 5 | October 14 | 13 |
| "Far Away" | Nickelback | 8 | September 23 | 6 | |
| September 23 | "Lips of an Angel" | Hinder | 3 | October 14 | 16 |
| September 30 | "Chain Hang Low" | Jibbs | 7 | October 21 | 5 |
| "How to Save a Life" | The Fray | 3 | October 7 | 19 | |
| "Money Maker" | Ludacris featuring Pharrell | 1 | October 28 | 11 | |
| "Too Little Too Late" | JoJo | 3 | September 30 | 6 | |
| October 7 | "Pullin' Me Back" | Chingy featuring Tyrese | 9 | October 7 | 2 |
| October 14 | "Smack That" | Akon featuring Eminem | 2 | November 4 | 17 |
| October 21 | "White & Nerdy" | "Weird Al" Yankovic | 9 | October 21 | 1 |
| October 28 | "My Love" | Justin Timberlake featuring T.I. | 1 | November 11 | 14 |
| November 4 | "Come to Me" | Diddy featuring Nicole Scherzinger | 9 | November 4 | 1 |
| November 11 | "Say Goodbye" | Chris Brown | 10 | November 11 | 2 |
| November 18 | "Irreplaceable" | Beyoncé | 1 | December 16 | 16 |
| November 25 | "Show Me What You Got" | Jay-Z | 8 | November 25 | 1 |
| December 2 | "I Wanna Love You" | Akon featuring Snoop Dogg | 1 | December 2 | 13 |
| "Shortie Like Mine" | Bow Wow featuring Chris Brown and Johntá Austin | 9 | December 16 | 5 | |
| December 9 | "Wind It Up" | Gwen Stefani | 6 | December 16 | 3 |
| Top ten entry date | Single | Artist(s) | Peak | Peak date | Weeks in top ten |
|---|---|---|---|---|---|
| September 17 | "Gold Digger" | Kanye West featuring Jamie Foxx | 1 | September 17 | 19 |
| September 24 | "My Humps" | The Black Eyed Peas | 3 | November 5 | 16 |
| October 8 | "Photograph" | Nickelback | 2 | October 22 | 17 |
| October 22 | "Run It!" | Chris Brown featuring Juelz Santana | 1 | November 26 | 17 |
| November 26 | "Stickwitu" | The Pussycat Dolls | 5 | December 31 | 12 |
| December 17 | "Don't Forget About Us" | Mariah Carey | 1 | December 31 | 8 |
| Top ten entry date | Single | Artist(s) | Peak | Peak date | Weeks in top ten |
|---|---|---|---|---|---|
| November 11 | "Fergalicious" | Fergie featuring will.i.am | 2 | January 13 | 14 |
| December 16 | "We Fly High" | Jim Jones | 5 | February 3 | 10 |
| December 23 | "Say It Right" | Nelly Furtado | 1 | February 24 | 14 |