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This is a list of singles that have peaked in the top 10 of the Billboard Hot 100 during 2008.
Lil Wayne scored six top ten hits during the year with "Lollipop", "A Milli", "Swagga Like Us", "Can't Believe It", "Got Money", and "Let It Rock", the most among all other artists.
– indicates single's top 10 entry was also its Hot 100 debut
– indicates Best performing song of the year| Top ten entry date | Single | Artist(s) | Peak | Peak date | Weeks in top ten |
|---|---|---|---|---|---|
| Singles from 2007 | |||||
| November 24 | "Low" (#1) | Flo Rida featuring T-Pain | 1 | January 5 | 23 |
| "Paralyzer" | Finger Eleven | 6 | January 5 | 9 | |
| Singles from 2008 | |||||
| January 5 | "Love Song" (#7) | Sara Bareilles | 4 | March 8 | 19 |
| January 26 | "Take You There" | Sean Kingston | 7 | February 9 | 7 |
| "With You" (#9) | Chris Brown | 2 | February 16 | 16 | |
| February 2 | "Don't Stop the Music" | Rihanna | 3 | February 16 | 10 |
| February 9 | "Sexual Eruption" | Snoop Dogg | 7 | March 1 | 6 |
| February 16 | "New Soul" | Yael Naïm | 7 | February 23 | 2 |
| February 23 | "Sorry" | Buckcherry | 9 | March 1 | 3 |
| March 1 | "Independent" | Webbie featuring Lil Boosie and Lil Phat | 9 | March 8 | 4 |
| March 15 | "Love in This Club" (#8) | Usher featuring Young Jeezy | 1 | March 15 | 16 |
| "No Air" (#6) | Jordin Sparks and Chris Brown | 3 | April 26 | 16 | |
| March 22 | "Sexy Can I" | Ray J featuring Yung Berg | 3 | April 5 | 14 |
| "Superstar" | Lupe Fiasco featuring Matthew Santos | 10 | March 22 | 2 | |
| March 29 | "Bleeding Love" (#2) | Leona Lewis | 1 | April 5 | 20 |
| April 5 | "Lollipop" (#4) | Lil Wayne featuring Static Major | 1 | May 3 | 19 |
| "Shawty Get Loose" | Lil Mama featuring Chris Brown and T-Pain | 10 | April 5 | 1 | |
| April 12 | "4 Minutes" | Madonna featuring Justin Timberlake and Timbaland | 3 | April 12 | 11 |
| "Touch My Body" | Mariah Carey | 1 | April 12 | 8 | |
| May 3 | "See You Again" | Miley Cyrus | 10 | May 3 | 1 |
| May 10 | "Forever" (#10) | Chris Brown | 2 | August 16 | 15 |
| May 17 | "Leavin'" | Jesse McCartney | 10 | May 17 | 3 |
| "Pocketful of Sunshine" | Natasha Bedingfield | 5 | July 5 | 11 | |
| May 24 | "Damaged" | Danity Kane | 10 | May 24 | 2 |
| "Take a Bow" | Rihanna | 1 | May 24 | 16 | |
| June 7 | "The Time of My Life" | David Cook | 3 | June 7 | 2 |
| "Viva la Vida" | Coldplay | 1 | June 28 | 16 | |
| June 14 | "I Kissed a Girl" | Katy Perry | 1 | July 5 | 14 |
| June 28 | "Shake It" | Metro Station | 10 | June 28 | 1 |
| July 5 | "7 Things" | Miley Cyrus | 9 | July 26 | 3 |
| "Bust It Baby (Part 2)" | Plies featuring Ne-Yo | 7 | July 12 | 4 | |
| "When I Grow Up" | The Pussycat Dolls | 9 | July 5 | 2 | |
| July 12 | "Burnin' Up" | Jonas Brothers featuring Big Rob | 5 | July 12 | 3 |
| "This Is Me" | Demi Lovato and Joe Jonas | 9 | July 12 | 1 | |
| July 26 | "A Milli" | Lil Wayne | 6 | August 9 | 5 |
| August 2 | "Dangerous" | Kardinal Offishall featuring Akon | 5 | September 6 | 8 |
| August 9 | "Disturbia" | Rihanna | 1 | August 23 | 14 |
| August 16 | "Tonight" | Jonas Brothers | 8 | August 16 | 1 |
| "Closer" | Ne-Yo | 7 | September 27 | 9 | |
| August 23 | "Paper Planes" | M.I.A. | 4 | September 27 | 10 |
| August 30 | "Crush" | David Archuleta | 2 | August 30 | 1 |
| "Change" | Taylor Swift | 10 | August 30 | 1 | |
| September 6 | "So What" | Pink | 1 | September 27 | 15 |
| "Whatever You Like" | T.I. | 1 | September 6 | 19 | |
| September 13 | "I'm Yours" | Jason Mraz | 6 | September 20 | 13 |
| September 20 | "In the Ayer" | Flo Rida featuring will.i.am | 9 | September 20 | 1 |
| September 27 | "Swagga Like Us" | Jay-Z and T.I. featuring Kanye West and Lil Wayne | 5 | September 27 | 1 |
| "American Boy" | Estelle featuring Kanye West | 9 | September 27 | 3 | |
| "Can't Believe It" | T-Pain featuring Lil Wayne | 7 | October 11 | 6 | |
| "Got Money" | Lil Wayne featuring T-Pain | 10 | September 27 | 1 | |
| October 4 | "Love Lockdown" | Kanye West | 3 | October 4 | 9 |
| "Hot n Cold" | Katy Perry | 3 | November 22 | 18 | |
| October 18 | "Keeps Gettin' Better" | Christina Aguilera | 7 | October 18 | 1 |
| "Gotta Be Somebody" | Nickelback | 10 | October 18 | 1 | |
| "Let It Rock" | Kevin Rudolf featuring Lil Wayne | 5 | October 18 | 10 | |
| "Live Your Life" | T.I. featuring Rihanna | 1 | October 18 | 18 | |
| October 25 | "Miss Independent" | Ne-Yo | 7 | December 13 | 7 |
| "Womanizer" | Britney Spears | 1 | October 25 | 13 | |
| November 1 | "Fearless" | Taylor Swift | 9 | November 1 | 1 |
| November 8 | "If I Were a Boy" | Beyoncé | 3 | November 8 | 10 |
| November 15 | "Right Now (Na Na Na)" | Akon | 8 | November 29 | 4 |
| December 6 | "Single Ladies (Put a Ring on It)" | Beyoncé | 1 | December 13 | 13 |
| December 20 | "Circus" | Britney Spears | 3 | December 20 | 5 |
| Top ten entry date | Single | Artist(s) | Peak | Peak date | Weeks in top ten |
|---|---|---|---|---|---|
| September 1 | "Crank That (Soulja Boy)" | Soulja Boy Tell 'Em | 1 | September 15 | 18 |
| October 6 | "Bubbly" | Colbie Caillat | 5 | October 27 | 17 |
| October 13 | "Apologize" (#5) | Timbaland featuring OneRepublic | 2 | November 10 | 25 |
| October 20 | "No One" (#3) | Alicia Keys | 1 | December 1 | 22 |
| November 3 | "Kiss Kiss" | Chris Brown featuring T-Pain | 1 | November 10 | 15 |
| "Hate That I Love You" | Rihanna featuring Ne-Yo | 7 | December 22 | 8 | |
| December 1 | "Clumsy" | Fergie | 5 | December 22 | 12 |
| December 22 | "Tattoo" | Jordin Sparks | 8 | December 29 | 6 |
| Top ten entry date | Single | Artist(s) | Peak | Peak date | Weeks in top ten |
|---|---|---|---|---|---|
| October 4 | "Love Story" | Taylor Swift | 4 | January 17 | 13 |
| November 22 | "Heartless" | Kanye West | 2 | February 21 | 16 |
| December 6 | "Just Dance" | Lady Gaga featuring Colby O'Donis | 1 | January 17 | 19 |