This is a list of Buffalo Bulls football players in the NFL draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 1952 | 18 | 1 | 206 | Les Molnar | New York Yanks | T |
| 1958 | 4 | 7 | 44 | Frank Woidzik | Los Angeles Rams | T |
| 1959 | 25 | 11 | 299 | Lou Reale | New York Giants | C |
| 1964 | 3 | 5 | 33 | Gerry Philbin | Detroit Lions | T |
| 1997 | 4 | 29 | 125 | Ed Ellis | New England Patriots | T |
| 2000 | 7 | 27 | 233 | Drew Haddad | Buffalo Bills | WR |
| 2008 | 6 | 3 | 169 | Trevor Scott | Oakland Raiders | DE |
| 7 | 29 | 236 | Jamey Richard | Indianapolis Colts | C | |
| 2010 | 6 | 24 | 193 | James Starks | Green Bay Packers | RB |
| 2011 | 5 | 12 | 143 | Josh Thomas | Dallas Cowboys | DB |
| 2013 | 5 | 14 | 147 | Steven Means | Tampa Bay Buccaneers | DE |
| 2014 | 1 | 5 | 5 | Khalil Mack | Oakland Raiders | LB |
| 2015 | 6 | 38 | 214 | Kristjan Sokoli | Seattle Seahawks | DT |
| 2017 | 7 | 33 | 251 | Mason Schreck | Cincinnati Bengals | TE |
| 2021 | 3 | 15 | 79 | Malcolm Koonce | Las Vegas Raiders | DE |