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The following is a list of persons from Spanish-speaking countries or of Hispanic descent who have travelled into space, sorted by date of first flight.
The first country listed is that of citizenship; the second, if any, is that of the Spanish-speaking country of birth or ancestry.
| # | Image | Name Birth date | Country | Comment | Missions (Launch date) |
|---|---|---|---|---|---|
| 1 |  | Arnaldo Tamayo Méndez January 29, 1942 |  Cuba | First person from Latin America to fly in space. First person of African descent in space. First Cuban in space. | Soyuz 38 (September 18, 1980) |
| 2 |  | Rodolfo Neri Vela February 19, 1952 |  Mexico | First Mexican in space. | STS-61-B (November 26, 1985) |
| 3 |  | Franklin Chang-Diaz April 5, 1950 |  United States (  Costa Rica) | First Costa Rican astronaut | STS-61-C (January 12, 1986) STS-34 (October 18, 1989) STS-46 (July 31, 1992) STS-60 (February 3, 1994) STS-75 (February 22, 1996) STS-91 (June 2, 1998) STS-111 (June 5, 2002) |
| 4 |  | Sidney M. Gutierrez June 27, 1951 | United States ( Mexico) | First U.S.-born Hispanic astronaut | STS-40 (June 5, 1991) STS-59 (April 9, 1994) |
| 5 |  | Ellen Ochoa May 10, 1958 | United States ( Mexico) | First female Hispanic astronaut | STS-56 (April 8, 1993) STS-66 (November 3, 1994) STS-96 (May 27, 1999) STS-110 (April 8, 2002) |
| 6 |  | Michael Lopez-Alegria May 30, 1958 | United States- Spain [1] ( Spain) | First Spanish-born astronaut | STS-73 (October 20, 1995) STS-92 (October 11, 2000) STS-113 (November 24, 2002) Soyuz TMA-9 (September 18, 2006) Axiom Mission 1 (April 8, 2022) |
| 7 |  | Carlos I. Noriega October 8, 1959 | United States (  Peru) | First Peruvian-born astronaut | STS-84 (May 15, 1997) STS-97 (November 30, 2000) |
| 8 |  | Pedro Duque March 14, 1963 | Spain | First Spanish astronaut without dual citizenship | STS-95 (October 29, 1998) Soyuz TMA-3/2 (October 18, 2003) |
| 9 |  | John D. Olivas May 25, 1965 | United States ( Mexico) | First Mexican-American Spacewalker | STS-117 (June 8, 2007) STS-128 (August 28, 2009) |
| 10 |  | George D. Zamka June 29, 1962 | United States (  Colombia) | STS-120 (October 23, 2007) STS-130 (February 8, 2010) | |
| 11 |  | Joseph M. Acaba May 17, 1967 | United States (  Puerto Rico) | First Puerto Rican astronaut | STS-119 (March 15, 2009) Soyuz TMA-04M (May 15, 2012) [2] Soyuz MS-06 (September 12, 2017) |
| 12 |  | José M. Hernández August 7, 1962 | United States ( Mexico) | First migrant farm worker in space. | STS-128 (August 28, 2009) |
| 13 |  | Serena M. Auñón April 9, 1976 | United States ( Cuba) | Soyuz MS-09 (June 6, 2018) | |
| 14 |  | Francisco Rubio December 11, 1975 | United States (  El Salvador) | First salvadoreño astronaut. | Soyuz MS-22 (Sept. 21, 2022) |
| # | Name Birth date | Country | Comment | Missions (Launch date) |
|---|---|---|---|---|
| 1 | Katya Echazarreta June 16, 1995 |  United States ( Mexico) | Suborbital flight to a height of 106 km | Blue Origin NS-21 (June 4, 2022) |
| 2 | Jesús Calleja April 11, 1995 | Spain | Suborbital flight to a height of 107 km | Blue Origin NS-30 (February 25, 2025) |
| 3 | Jaime Alemán November 14, 1953 |  Panama | Suborbital flight to a height of 104 km | Blue Origin NS-30 (May 31, 2025) |
| 4 | Aymette (Amy) Medina Jorge | Puerto Rico | Suborbital flight to a height of 104 km | Blue Origin NS-30 (May 31, 2025) |
| Image | Name Birth date | Country | Comment |
|---|---|---|---|
| José López Falcón February 8, 1950 | Cuba | Backup for Arnaldo Tamayo Mendez on Soyuz 38 | |
 | Ricardo Peralta y Fabi | Mexico | Backup for Rodolfo Neri Vela on STS-61-B |
 | Fernando Caldeiro June 12, 1958 | United States (  Argentina) | Died October 3, 2009. |
 | Marcos Berríos 1984 | United States ( Puerto Rico) | Selected as part of NASA Astronaut Group 23 |