These are the Official Charts Company UK Official Indie Chart number one hits of 2001. [1]
| Issue date | Song | Artist |
|---|---|---|
| 6 January | "Can We Fix It?" | Bob the Builder |
| 13 January | "It's the Way You Make Me Feel" | Steps |
| 13 January | ||
| 20 January | "Buck Rogers" | Feeder |
| 27 January | ||
| 3 February | "Oh No" | Mos Def with Pharoahe Monch & Nate Dogg |
| 10 February | "Shining Light" | Ash |
| 17 February | "Stutter" | Joe |
| 24 February | "The Call" | Backstreet Boys |
| 3 March | "Stutter" | Joe |
| 10 March | "The Vision" | Mario Più Pts. DJ Arabesque |
| 17 March | ||
| 24 March | "Plug In Baby" | Muse |
| 31 March | "Mr. Writer" | Stereophonics |
| 7 April | ||
| 14 April | "Burn Baby Burn" | Ash |
| 21 April | "Flesh" | Jan Johnson |
| 28 April | "Straight Up (No Bends)" | Brian Harvey |
| 5 May | "Dream On" | Depeche Mode |
| 12 May | "Strange World" | Push |
| 19 May | "Pissing in the Wind" | Badly Drawn Boy |
| 26 May | "Ya Don't See the Signs" | Mark B & Blade |
| 2 June | "Star 69" | Fat Boy Slim |
| 9 June | "No Flow" | Lisa Roxanne |
| 16 June | "Romeo" | Basement Jaxx |
| 23 June | "Have a Nice Day" | Stereophonics |
| 30 June | "Romeo" | Basement Jaxx |
| 7 July | "Hard to Explain"/"New York City Cops" | The Strokes |
| 14 July | "Turn" | Feeder |
| 21 July | "Pop" | NSYNC |
| 28 July | ||
| 4 August | "Do the Lollipop" | Tweenies |
| 11 August | "I Feel Loved" | Depeche Mode |
| 18 August | "Hidden Place" | Björk |
| 25 August | "Superstylin'" | Groove Armada |
| 1 September | ||
| 8 September | ||
| 15 September | "Mambo No. 5" | Bob the Builder |
| 22 September | ||
| 29 September | ||
| 6 October | "Chain Reaction"/"One for Sorrow" | Steps |
| 13 October | ||
| 20 October | ||
| 27 October | "I'm a Slave 4 U" | Britney Spears |
| 3 November | ||
| 10 November | ||
| 17 November | "Last Nite" | The Strokes |
| 24 November | "Hotel Yorba" | The White Stripes |
| 1 December | "Hyper Music/Feeling Good" | Muse |
| 8 December | "ResuRection" | PPK |
| 15 December | "Handbags and Gladrags" | The Stereophonics |
| 22 December | ||
| 29 December | "How Wonderful You Are" | Gordon Haskell |