These are the Official Charts Company's UK Independent Singles Chart number-one singles of 2016.
| † | Best-selling indie single of the year |
| Chart date (week ending) | Song | Artist(s) | Record label | References |
|---|---|---|---|---|
| 7 January | "Hello" | Adele | XL | [1] |
| 14 January | [2] | |||
| 21 January | "Sweet Lovin'" | Sigala featuring Bryn Christopher | Ministry of Sound | [3] |
| 28 January | "Hello" | Adele | XL | [4] |
| 4 February | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | [5] |
| 11 February | [6] | |||
| 18 February | [7] | |||
| 25 February | "Swings & Waterslides" | Viola Beach | Fuller Beans | [8] |
| 3 March | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | [9] |
| 10 March | "When We Were Young" | Adele | XL | [10] |
| 17 March | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | [11] |
| 24 March | [12] | |||
| 31 March | "Say You Do" | Sigala featuring DJ Fresh and Imani Williams | Ministry Of Sound | [13] |
| 7 April | [14] | |||
| 14 April | "Light It Up" | Major Lazer featuring Nyla and Fuse ODG | Because Music | [15] |
| 21 April | [16] | |||
| 28 April | [17] | |||
| 5 May | [18] | |||
| 12 May | [19] | |||
| 19 May | [20] | |||
| 26 May | [21] | |||
| 2 June | [22] | |||
| 9 June | [23] | |||
| 16 June | "Send My Love (To Your New Lover)" | Adele | XL | [24] |
| 23 June | "I'll Be There" | The Neales | ZY | [25] |
| 30 June | "Give Me Your Love" | Sigala featuring John Newman and Nile Rodgers | Ministry of Sound | [26] |
| 7 July | "Send My Love (To Your New Lover)" | Adele | XL | [27] |
| 14 July | [28] | |||
| 21 July | [29] | |||
| 28 July | [30] | |||
| 4 August [a] | "Cold Water" † | Major Lazer featuring Justin Bieber and MØ | Because Music | [31] |
| 11 August [a] | [32] | |||
| 18 August [a] | [33] | |||
| 25 August [a] | [34] | |||
| 1 September [a] | [35] | |||
| 8 September | [36] | |||
| 15 September | [37] | |||
| 22 September | [38] | |||
| 29 September | [39] | |||
| 6 October | [40] | |||
| 13 October | [41] | |||
| 20 October | [42] | |||
| 27 October | [43] | |||
| 3 November | [44] | |||
| 10 November | [45] | |||
| 17 November | [46] | |||
| 24 November | [47] | |||
| 1 December | [48] | |||
| 8 December | [49] | |||
| 15 December | [50] | |||
| 22 December | [51] | |||
| 29 December | "Glad All Over" | The Dave Clark Five | Dave Clark | [52] |
| Position | Artist | Weeks at number one |
|---|---|---|
| 1 | Major Lazer | 36 |
| 2 | Adele | 9 |
| 3 | Sigala | 4 |
| 4 | DJ Fresh (as featuring) | 2 |
| 4 | Imani Williams (as featuring) | 2 |
| 5 | The Dave Clark Five | 1 |
| 5 | The Neales | 1 |
| 5 | Viola Beach | 1 |