List of breast cancer cell lines

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Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. This is a list of major breast cancer cell lines that are primarily used in breast cancer research. [Notes 1]

Contents

List of cell lines

Cell linePrimary tumorOrigin of cells Estrogen receptors Progesterone receptors ERBB2 amplificationMutated TP53 [Notes 2] Tumorigenic in miceReferenceExternal links
600MPEInvasive ductal carcinoma+ [3] Cellosaurus
AMJ13 Invasive ductal carcinoma Primary YesYesNo-- [4] Cellosaurus
AU565Adenocarcinoma+ [3] Cellosaurus
BT-20 Invasive ductal carcinoma Primary NoNoNoYesYes [5] Cellosaurus
BT-474Invasive ductal carcinoma Primary YesYesYesYesYes [6] Cellosaurus
BT-483Invasive ductal carcinoma++ [3] Cellosaurus
BT-549Invasive ductal carcinoma+ [3] Cellosaurus
Evsa-TInvasive ductal carcinoma, mucin-producing, signet-ring type Metastasis (ascites)NoYes ?Yes ? [7] Cellosaurus
Hs578TInvasive ductal carcinoma Primary NoNoNoYesNo [8] Cellosaurus
MCF-7 Invasive ductal carcinoma Metastasis (pleural effusion)YesYes [9] NoNo (wild-type)Yes (with estrogen supplementation) [10] Cellosaurus
MDA-MB-231Adenocarcinoma Metastasis (pleural effusion)NoNoNoYesYes [11] Cellosaurus
SkBr3 Invasive ductal carcinoma Metastasis (pleural effusion)NoNoYesYesNo [12] Cellosaurus
T-47D Invasive ductal carcinoma Metastasis (pleural effusion)YesYesNoYesYes (with estrogen supplementation) [13] Cellosaurus
ZR-75-1 Invasive ductal carcinoma [14] Cellosaurus

Notes

  1. The original list was mainly based on the work of Lacroix and Leclercq (2004). [1]
  2. For more data on the nature of TP53 mutations in breast cancer cell lines, see Lacroix et al. (2006). [2]

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References

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