Liza Makowski Hayes | |
---|---|
Born | Florida, US |
Spouse | D. Neil Hayes |
Academic background | |
Education | BS, Biology, 1994, Boston College MSc, Medical Sciences, 1998, Harvard Medical School PhD, Nutritional Biochemistry, 2003, Harvard T.H. Chan School of Public Health Duke University |
Thesis | The role of fatty acid binding protein aP2 in atherosclerosis and macrophage biology (2003) |
Academic work | |
Institutions | University of Tennessee Health Science Center University of North Carolina at Chapel Hill Geron Corporation |
Website | makowskilab |
Liza Makowski Hayes is an American nutritional biochemist. As a professor at the University of Tennessee,her research focuses on how metabolic stress and inflammation alters the progression of diseases,specifically obesity and cancer.
Makowski Hayes was born and raised in Florida before leaving to earn her Bachelor of Science degree in biology from Boston College. Upon graduation,she moved to California and worked for Geron Corporation,where she focused on stem cells and cancer research. During her second year with the company,Makowski Hayes returned home to assist with her ill mother before enrolling at Harvard Medical School and Harvard T.H. Chan School of Public Health. Following receiving her medical degree,Makowski Hayes served a post-doctoral fellowship at Duke University's Sarah W. Stedman Center for Nutrition and Metabolism. [1]
Upon finishing her post-doctoral fellowship,Makowski Hayes joined the faculty in the Division of Biochemistry at the University of North Carolina at Chapel Hill (UNC) and established her lab in The Michael Hooker Research Center. [1] The Makowski Lab studies metabolism and inflammation of white blood cells called macrophages and how that relates to obesity and cancer. [2]
Beyond cancer research,Makowski Hayes and her research laboratory also began studying the American obesity epidemic. In 2007,Makowski Hayes and Melissa Troester became co-principal investigators on a National Institute of Environmental Health Sciences Breast Cancer and Environment Research Program study focused on how factors such as pregnancy and obesity may promote susceptibility of breast cancer that is more prevalent in young,African American patients. [3] In 2011,she showed that feeding the rats a Western pattern diet,consisting of highly palatable,energy-dense foods,caused severe weight gain,tissue inflammation and diabetes. [4] She also demonstrated that sugar intake could play an important role in the promotion of obesity-related insulin resistance [5] and found a correlation between weight loss and a reducing in the progression of basal-like breast cancer. In order to find this correlation,her research team tracked changes in mammary gland tissue which were drivers of basal-like breast cancer. [6]
Makowski Hayes continued to work alongside Troester during her tenure at UNC and co-launched the myBCrisk website to help women learn about their risk for breast cancer. The website specifically focused on the increased risk of cancer amongst black women and included a tool for assessing personal risk factors and videos of young Black cancer survivors. The project was funded by the National Institute of Environmental Health Sciences with support from the National Cancer Institute and the Avon Foundation. [7] She also accepted an assistant professor position at the University of Tennessee Health Science Center where she received funding from the American Heart Association Beginning Grant-in-Aid for her project "The Role of Macrophage Substrate Metabolism in Atherosclerosis." [8]
During the COVID-19 pandemic in North America,Makowski Hayes and Joseph F. Pierre received a $2.1 million,five-year grant from the National Cancer Institute to examine how the microbiome impacts the immune system and response to immunotherapy for triple negative breast cancer. [9] Her research was also supported by a $100,000 grant from The Mary Kay Foundation. [10]
Makowski Hayes is married to oncologist and physician-scientist D. Neil Hayes,with whom she shares two children. [11]
Macrophages are a type of white blood cell of the innate immune system that engulf and digest pathogens,such as cancer cells,microbes,cellular debris,and foreign substances,which do not have proteins that are specific to healthy body cells on their surface. This process is called phagocytosis,which acts to defend the host against infection and injury.
Fatty liver disease (FLD),also known as hepatic steatosis,is a condition where excess fat builds up in the liver. Often there are no or few symptoms. Occasionally there may be tiredness or pain in the upper right side of the abdomen. Complications may include cirrhosis,liver cancer,and esophageal varices.
Steven H. Zeisel is a Kenan Distinguished University Professor in Nutrition and Pediatrics;former Chairman,Department of Nutrition;Director Nutrition Research Institute,Director UNC Human Clinical Nutrition Research Center,Director UNC Center for Excellence in Children’s Nutrition,School of Public Health,University of North Carolina at Chapel Hill.
Dietary factors are recognized as having a significant effect on the risk of cancers,with different dietary elements both increasing and reducing risk. Diet and obesity may be related to up to 30–35% of cancer deaths,while physical inactivity appears to be related to 7% risk of cancer occurrence.
The Pennington Biomedical Research Center is a health science-focused research center in Baton Rouge,Louisiana. It is part of the Louisiana State University System and conducts clinical,basic,and population science research. It is the largest academically-based nutrition research center in the world,with the greatest number of obesity researchers on faculty. The center's over 500 employees occupy several buildings on the 222-acre (0.90 km2) campus. The center was designed by the Baton Rouge architect John Desmond.
The Jean Mayer Human Nutrition Research Center on Aging (HNRCA),located in Boston,Massachusetts,is one of six human nutrition research centers in the United States supported by the United States Department of Agriculture Agricultural Research Service. The goal of the HNRCA,which is managed by Tufts University,is to explore the relationship between nutrition,physical activity,and healthy and active aging.
The association between obesity,as defined by a body mass index of 30 or higher,and risk of a variety of types of cancer has received a considerable amount of attention in recent years. Obesity has been associated with an increased risk of esophageal cancer,pancreatic cancer,colorectal cancer,breast cancer,endometrial cancer,kidney cancer,thyroid cancer,liver cancer and gallbladder cancer. Obesity may also lead to increased cancer-related mortality. Obesity has also been described as the fat tissue disease version of cancer,where common features between the two diseases were suggested for the first time.
Christos Socrates Mantzoros is a Greek American physician-scientist,practicing internist-endocrinologist,teacher and researcher. He is a professor of medicine at Harvard Medical School and an adjunct professor at Boston University School of Medicine. He currently serves as the chief of endocrinology,diabetes and metabolism at the VA Boston Healthcare System,where he created de novo a leading academic division true to its tripartite mission and as the founding director of human nutrition at Beth Israel Deaconess Medical Center (BIDMC),Harvard Medical School. Finally,he holds the editor-in-chief position of the journal Metabolism:Clinical and Experimental.
Rebecca Hasson is an Associate Professor of Kinesiology at the University of Michigan. She researches the causes and consequences of pediatric obesity,how the environment impacts obesity related metabolic risk factors to inform health policies.
Thea D. Tlsty is an American pathologist and professor of pathology at the University of California,San Francisco (UCSF). She is known for her research in cancer biology and her involvement in the discovery of cells that may be at the origin of metaplastic cancer,an invasive form of breast cancer.
Penny Gordon-Larsen is an American nutrition scientist. She is the Carla Smith Chamblee Distinguished Professor of Global Nutrition at the UNC Gillings School of Global Public Health at the University of North Carolina at Chapel Hill,where she served as Associate Dean for Research from 2018 to 2022. In March 2022,she was named interim Vice Chancellor for Research for the University of North Carolina at Chapel Hill. She is also a Faculty Fellow at the Carolina Population Center. Dr. Gordon-Larsen’s NIH-funded research portfolio focuses on individual-,household-,and community-level susceptibility to obesity and its cardiometabolic consequences,and her work ranges from molecular and genetic to environmental and societal-level factors. She was the 2015 president of The Obesity Society and a member of the National Institute of Diabetes and Digestive and Kidney Diseases Clinical Obesity Research Panel (CORP).
Wendy Rosamund Brewster is a Professor of Obstetrics and Gynaecology and Director of the Center for Women's Health Research at the University of North Carolina at Chapel Hill.
Mary Kathryn "Katie" Haltiwanger Schmitz is an American exercise physiologist. She is the Associate Director of Population Sciences at Penn State University College of Medicine and a Full Professor at the Perelman School of Medicine at the University of Pennsylvania.
Allison Elizabeth Aiello is an American epidemiologist. She is a professor of Epidemiology and a Carolina Population Center Fellow at the University of North Carolina at Chapel Hill. Aiello is an expert in influenza,investigating non-pharmaceutical interventions for flu prevention.
Katherine A. Hoadley is an American breast cancer researcher. As of 2017,she has served as the Associate Director of Cancer Genomics for the High-Throughput Sequencing Facility at UNC Lineberger Comprehensive Cancer Center. Her research is focused on understanding the biology of cancer through gene expression analyses and integrative genomic approaches.
David "Neil" Hayes is an American oncologist and physician-scientist. He is the Van Vleet Endowed Professor in Medical Oncology and the division chief of haematology and oncology at the University of Tennessee Health Science Center. As a result of his research,Hayes was elected a Member of the American Society for Clinical Investigation.
Mary Violet Relling is an American pharmacogeneticist. Relling's research focuses on pharmacokinetics and pharmacodynamics in children and how genome variability influences a child's response to cancer chemotherapy.
Eliana Perrin is an American pediatrician,researcher,and Bloomberg Distinguished Professor of Primary Care with joint appointments with tenure in the Department of Pediatrics in the School of Medicine and in the School of Nursing at Johns Hopkins University. She was elected a member of the American Pediatric Society in 2021.
Claudia Fischbach is a German biophysicist who is the Stanley Bryer 1946 Professor of Biomedical Engineering at Cornell University. She is Director of the Cornell Physical Sciences Oncology Centre on the Physics of Cancer Metabolism.
Marian L. Neuhouser is an American epidemiologist who is the Head of Cancer Prevention at the Fred Hutchinson Cancer Center. Her research focuses on the role of nutrition in the prevention of cancer.
Liza Makowski Hayes publications indexed by Google Scholar