M-28 is an east–west state trunkline highway that traverses nearly all of the Upper Peninsula of the U.S. state of Michigan, from Wakefield to near Sault Ste. Marie in Bruce Township. Along with US Highway 2 (US 2), M-28 forms a pair of primary highways linking the Upper Peninsula from end to end, providing a major access route for traffic from Michigan and Canada along the southern shore of Lake Superior. M-28 is the longest state trunkline in Michigan numbered with the "M-" prefix at 290.373 miles (467.310 km). The entire highway is listed on the National Highway System, while three sections of M-28 are part of the Lake Superior Circle Tour. M-28 also carries two memorial highway designations along its route.
M-22 is a state trunkline highway in the US state of Michigan. It is 116.7 miles (187.8 km) long and follows the Lake Michigan shoreline of the Leelanau Peninsula, making up a portion of the Lake Michigan Circle Tour. It also passes through the Sleeping Bear Dunes National Lakeshore. The highway is U-shaped as it rounds the peninsula running through tourist areas in Leland and Suttons Bay in addition to the national lakeshore.
M-108 was a state trunkline highway in the US state of Michigan. The highway followed Nicolet Street, although some maps also labeled it as Mackinaw Highway. The road was on the boundary between Emmet and Cheboygan counties.
M-204 is a state trunkline highway that runs across the Leelanau Peninsula between Leland and Suttons Bay in the northwestern Lower Peninsula of the US state of Michigan. The trunkline runs through a rural section of Leelanau County, connecting two villages with the county seat. Originally a gravel road in 1933, it was later paved within the first three years of existence. Segments were realigned to straighten curves in the late 1930s and early 1970s near the villages of Lake Leelanau and Suttons Bay.
M-142 is an east–west state trunkline highway in The Thumb region of the US state of Michigan. It is a "trans-peninsular" highway in that it travels through an agricultural area from Bay Port on Saginaw Bay to Harbor Beach on Lake Huron. The current trunkline in Huron County was originally parts of other state highways that date back to the initial 1919 signposting of the state highway system in the state. The designation was applied in 1939, and the road has remained unchanged since it was completely paved in the 1950s. One other highway, near Lake City, carried the number in the 1930s.
M-143, also known as Michigan Avenue, is a previously unsigned spur state trunkline highway in the south central region of the US state of Michigan. The M-143 portion of Michigan Avenue runs from the East Lansing city limit to a junction with M-43 at Grand River Avenue. This highway is the second time that there has been an M-143 in Michigan. The first was a connection to the original Cheboygan State Park. The current is a remnant of M-43 in the Lansing area.
M-85, also known as Fort Street or Fort Road for its entire length, is a state trunkline highway in the U.S. state of Michigan. The highway serves several Downriver suburbs of Detroit, as well as neighborhoods in the city itself. From its southern terminus at exit 28 on Interstate 75 (I-75) to its second interchange with exit 43 on I-75 in southwest Detroit, M-85 is part of the Lake Erie Circle Tour. In between, it serves mostly residential areas running parallel to a pair of rail lines; the highway carries between 5,000 and 43,000 vehicles per day on average. Once in the city of Detroit, Fort Street runs parallel to I-75 for several miles before they separate near the Ambassador Bridge. The northern end of M-85 is at the intersection with Griswold Street in downtown Detroit, one block away from Campus Martius Park.
M-294 is a state trunkline highway in Calhoun County in the US state of Michigan. It is one of a handful of highways that was established or realigned as a result of a rationalization process initiated in 1998 during the tenure of Governor John Engler. M-294 is approximately two miles (3.2 km) east of Interstate 194 (I-194) and connects M-96 with I-94 southeast of Battle Creek.
M-331 was an unsigned state trunkline highway in the U.S. state of Michigan located within the city of Kalamazoo. It ran from the southern city limits north into downtown Kalamazoo. This was one of many highways to be established or realigned as a result of a rationalization process initiated in 1998 during the tenure of Governor John Engler. M-331 used streets in Kalamazoo that were once part of US Highway 131 (US 131) before a freeway was built that bypassed the downtown area. In 2019, the City of Kalamazoo and the Michigan Department of Transportation (MDOT) agreed to transfer control of various streets from state to city jurisdiction, and M-331 was decommissioned as a result.
M-199 is a state trunkline highway near Albion in the US state of Michigan. The western terminus of the 4.030-mile-long (6.486 km) road is in Sheridan Township at exit 119 off Interstate 94 (I-94). The eastern terminus is a junction with Business Loop I-94 downtown Albion. The entire road is within Calhoun County and runs through rural farm fields outside of Albion; in town it is a residential street. The M-199 designation had previously been applied to a highway in the Upper Peninsula in the 1930s. The current highway was previously part of other highways in the first half of the 20th century before it was transferred to local control around 1960. It was later transferred back to state control in 1998 and remains unchanged since.
M-553 is a north–south state trunkline highway in the Upper Peninsula (UP) of the US state of Michigan. It connects M-35 near Gwinn with the Marquette Bypass, an expressway carrying US Highway 41 (US 41) and M-28 in Marquette. M-553 connects Marquette with Marquette Sawyer Regional Airport at the unincorporated community of K.I. Sawyer, the former site of a US Air Force base, in the Sands Plains area of Marquette County. The intersection with County Road 480 (CR 480) in Sands Township, known locally as the Crossroads, is the site of several businesses. North of this location, M-553 runs through some hilly terrain around a local ski hill.
M-67 is a north–south state trunkline highway in the Upper Peninsula of the U.S. state of Michigan. It connects with US Highway 41 (US 41) and M-94 between Trenary and Chatham. The highway has largely been unchanged during its history, although the highways that connect to M-67 on each end have changed several times.
M-183 is a north–south state trunkline highway in the Upper Peninsula of the US state of Michigan. It serves Fayette State Park as an access route from US Highway 2 (US 2). The highway runs through rural farmlands of the Garden Peninsula and next to Big Bay de Noc, a bay of Lake Michigan. The community at Fayette dates back to the 1860s. It has been a state park since the late 1950s, and the connecting road has been a state highway since the 1980s.
M-188 is a 4.559-mile-long (7.337 km) state trunkline highway in the US state of Michigan. It runs from Eaton Rapids to the VFW National Home for Children, southeast of town through a rural area. Approximately 1,000 vehicles each day use a highway that was first designated in the 1930s and paved in the 1940s.
M-81 is an east–west state trunkline highway in the Lower Peninsula of the US state of Michigan. The trunkline travels from the city of Saginaw at the junction with M-13 to the junction with M-53 east of Cass City over the county line in Greenleaf Township in northwestern Sanilac County in The Thumb area of the state. Outside of the cities and villages along its route, M-81 passes through mostly rural farm country. Near Saginaw it intersects the freeway that carries both Interstate 75 (I-75) and US Highway 23 (US 23) in an industrial area.
M-109 is the designation of a state trunkline highway in the Lower Peninsula of the US state of Michigan that runs between Empire and Glen Arbor. The highway is a loop connected to M-22 at both ends that allows tourists access to Sleeping Bear Dunes National Lakeshore and the Pierce Stocking Scenic Drive located on a section of sandy forest land between Lake Michigan and Glen Lake. The trunkline traverses an area named the "Most Beautiful Place in America" by Good Morning America, the morning show on ABC. The highway was designated by 1929 and fully paved in 1939.
M-211 is a state trunkline highway in the Lower Peninsula (LP) of Michigan that connects the community of Onaway with Onaway State Park. The highway runs through farmland and forests along the 5.174-mile (8.327 km) route to the park. The trunkline was originally designated M-95 from 1919 until 1934. In that year, the designation was moved to a different highway in the Upper Peninsula (UP), and the state park connector was given the current number. The highway was last changed by 1960 when paving was completed.
M-217, also known as Michiana Parkway, is a multi-lane state trunkline highway in the U.S. state of Michigan. The Michiana Parkway, which extends into Indiana, was constructed as a joint effort of the Michigan Department of Transportation (MDOT), the Cass County Road Commission and the Elkhart County Highway Department. Michigan's segment of the parkway is 1.563 miles (2.515 km) long continuing County Road 17 (CR 17) in Elkhart County north into the state.
M-138 is a 20-mile-long (32 km) east–west state trunkline highway in The Thumb region of the US state of Michigan. The highway runs from a junction with M-15 west of the unincorporated community of Munger in Bay County to the intersection with M-24 east of Akron in Tuscola County. The trunkline runs through rural agricultural areas outside of the villages and communities it serves. It was designated in the 1930s and extended in the 1940s. M-138 was truncated in the 1990s as well.
M-152 is a state trunkline highway in the US state of Michigan in Cass and Van Buren counties. The highway runs through the Sister Lakes area providing access to the lake cabins and adjoining farmlands. The highway has existed mostly unchanged since the designation was commissioned in the 1930s.
M-22 in Northport 
CR 640 north of Northport
