MAF1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | MAF1 , MAF1 homolog, negative regulator of RNA polymerase III | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 610210 MGI: 1916127 HomoloGene: 49867 GeneCards: MAF1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene. [5] [6] [7]
This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [7]
In eukaryote cells, RNA polymerase III is a protein that transcribes DNA to synthesize ribosomal 5S rRNA, tRNA and other small RNAs.
DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the POLR2H gene.
Transcription factor IIIB 90 kDa subunit is a protein that in humans is encoded by the BRF1 gene.
Transcription elongation factor SPT4 is a protein that in humans is encoded by the SUPT4H1 gene.
Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.
Nucleolar complex protein 2 homolog is a protein that in humans is encoded by the NOC2L gene.
DNA-directed RNA polymerase I subunit RPA2 is an enzyme that in humans is encoded by the POLR1B gene.
Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.
Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.
Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.
ETS homologous factor is a protein that in humans is encoded by the EHF gene. This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.
mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene.
DNA-directed RNA polymerase III subunit RPC10 is an enzyme that in humans is encoded by the POLR3K gene.
snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.
Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.
Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene. It forms part of the Mediator complex.
Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene.
DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.
RNA polymerase-associated protein LEO1 is an enzyme that in humans is encoded by the LEO1 gene.
DNA-directed RNA polymerase III subunit RPC5 is an enzyme that in humans is encoded by the POLR3E gene.