MAF1

Last updated
MAF1
Cyrstal Structure of Repressor of RNA polymerase III transcription MAF1.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAF1 , MAF1 homolog, negative regulator of RNA polymerase III
External IDs OMIM: 610210 MGI: 1916127 HomoloGene: 49867 GeneCards: MAF1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032272

NM_001164607
NM_001164608
NM_026859

RefSeq (protein)

NP_115648

NP_001158079
NP_001158080
NP_081135

Location (UCSC) Chr 8: 144.1 – 144.11 Mb Chr 15: 76.24 – 76.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene. [5] [6] [7]

This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [7]

Related Research Articles

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<span class="mw-page-title-main">POLR1B</span>

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<span class="mw-page-title-main">BDP1</span>

Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.

<span class="mw-page-title-main">MED31</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.

<span class="mw-page-title-main">MED7</span>

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<span class="mw-page-title-main">POLR3K</span>

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<span class="mw-page-title-main">ZNF143</span> Protein-coding gene

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<span class="mw-page-title-main">MED27</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Transcription factor IIIB 50 kDa subunit</span> Protein-coding gene in the species Homo sapiens

Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene.

<span class="mw-page-title-main">POLR3D</span> Protein-coding gene in the species Homo sapiens

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.

<span class="mw-page-title-main">LEO1</span>

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000179632 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022553 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
  6. Pluta K, Lefebvre O, Martin NC, Smagowicz WJ, Stanford DR, Ellis SR, Hopper AK, Sentenac A, Boguta M (Jul 2001). "Maf1p, a Negative Effector of RNA Polymerase III in Saccharomyces cerevisiae". Mol Cell Biol. 21 (15): 5031–40. doi:10.1128/MCB.21.15.5031-5040.2001. PMC   87229 . PMID   11438659.
  7. 1 2 "Entrez Gene: MAF1 MAF1 homolog (S. cerevisiae)".

Further reading