MAGEA1

Last updated
MAGEA1
PDB 1w72 EBI.jpg
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases MAGEA1 , CT1.1, MAGE1, MAGE family member A1
External IDs OMIM: 300016 HomoloGene: 88717 GeneCards: MAGEA1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004988

n/a

RefSeq (protein)

NP_004979

n/a

Location (UCSC) Chr X: 153.18 – 153.18 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene. [3]

Contents

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [4]

Related Research Articles

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Melanocyte protein PMEL also known as premelanosome protein (PMEL) or silver locus protein homolog (SILV) is a protein that in humans is encoded by the PMEL gene. Its gene product may be referred to as PMEL, silver, ME20, gp100 or Pmel17.

<span class="mw-page-title-main">MAGEA3</span> Protein-coding gene in humans

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<span class="mw-page-title-main">PRAME</span>

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<span class="mw-page-title-main">MLANA</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">MAGEA2</span> Protein-coding gene in humans

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<span class="mw-page-title-main">Mitochondrial ribosomal protein L28</span> Protein-coding gene in the species Homo sapiens

39S ribosomal protein L28, mitochondrial is a protein that in humans is encoded by the MRPL28 gene.

<span class="mw-page-title-main">MAGEC2</span> Protein-coding gene in humans

Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene.

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Melanoma-associated antigen D2 is a protein that in humans is encoded by the MAGED2 gene.

<span class="mw-page-title-main">MAGEB2</span> Protein-coding gene in humans

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.

<span class="mw-page-title-main">MAGEH1</span> Protein-coding gene in humans

Melanoma-associated antigen H1 is a protein that in humans is encoded by the MAGEH1 gene.

<span class="mw-page-title-main">MAGEA11</span> Protein-coding gene in humans

Melanoma-associated antigen 11 is a protein that in humans is encoded by the MAGEA11 gene. It is also involved in the androgen and progesterone receptor signaling pathways.

<span class="mw-page-title-main">MAGEA12</span> Protein-coding gene in humans

Melanoma-associated antigen 12 is a protein that in humans is encoded by the MAGEA12 gene.

<span class="mw-page-title-main">MAGED4B</span> Protein-coding gene in humans

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<span class="mw-page-title-main">MAGEA9</span> Protein-coding gene in humans

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Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a locus of immune activation. Thus, they are often classified as tumor antigens. The expression of CT antigens in various malignancies is heterogeneous and often correlates with tumor progression. CT antigens have been described in melanoma, liver cancer, lung cancer, bladder cancer, and pediatric tumors such as neuroblastoma. Gametogenesis offers an important role for many of these antigens in the differentiation, migration, and cell division of primordial germ cells, spermatogonia spermatocytes and spermatids. Because of their tumor-restricted expression and strong in vivo immunogenicity, CT antigens are identified as ideal targets for tumor specific immunotherapeutic approaches and prompted the development of several clinical trials of CT antigens-based vaccine therapy. CT antigens have been found to have at least 70 families so far, including about 140 members, most of which are expressed during spermatogenesis. Their expression are mainly regulated by epigenetic events, specifically, DNA methylation.

<span class="mw-page-title-main">Tumor antigens recognized by T lymphocytes</span>

T lymphocytes are cells of the immune system that attack and destroy virus-infected cells, tumor cells and cells from transplanted organs. This occurs because each T cell is endowed with a highly specific receptor that can bind to an antigen present at the surface of another cell. The T cell receptor binds to a complex formed by a surface protein named "MHC" and a small peptide of about 9 amino-acids, which is located in a groove of the MHC molecule. This peptide can originate from a protein that remains within the cell. Whereas each T cell recognizes a single antigen, collectively the T cells are endowed with a large diversity of receptors targeted at a wide variety of antigens. T cells originate in the thymus. There a process named central tolerance eliminates the T cells that have a receptor recognizing an antigen present on normal cells of the organism. This enables the T cells to eliminate cells with "foreign" or "abnormal" antigens without harming the normal cells.

<span class="mw-page-title-main">MAGEA10</span> Protein-coding gene in humans

MAGEA10 is a protein-coding gene in humans clustered at chromosomal location Xq28.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198681 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (Jan 1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7. doi:10.1126/science.1840703. PMID   1840703.
  4. "Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)".

Further reading