MAGEA10

MAGEA10
Identifiers
Aliases	MAGEA10 , CT1.10, MAGE10, MAGE family member A10
External IDs	OMIM: 300343 MGI: 3588211 HomoloGene: 121621 GeneCards: MAGEA10
Gene location (Human)
Chr.	X chromosome (human)
End	152,138,578 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	71,430,464 bp
RNA expression pattern
	Top expressed in
	placenta; ; renal cortex; ; urinary bladder; ; vagina; ; gallbladder;
	Top expressed in
	secondary oocyte; ; spermatid; ; spermatocyte; ; testicle; ; blastocyst;
	More reference expression data
	n/a
Orthologs
	4109
	236852
	ENSG00000124260
	ENSMUSG00000043453
	P43363
	A2AMW4
	NM_021048 ; NM_001011543 ; NM_001251828
	NM_001085506
	NP_001011543 ; NP_001238757 ; NP_066386
	NP_001078975
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

MAGEA10 (MAGE family member A10) is a protein-coding gene in humans clustered at chromosomal location Xq28. ^[5]

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.

Related Research Articles

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) also known as CD66a, is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.

Cancer/testis antigen 1 also known as LAGE2 or LAGE2B is a protein that in humans is encoded by the CTAG1B gene. It is most often referenced by its alias NY-ESO-1.

Melanoma-associated antigen 3 (MAGE-A3) is a protein that in humans is encoded by the MAGEA3 gene.

Melanoma-associated antigen D1 is a protein that in humans is encoded by the MAGED1 gene.

Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene.

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.

Melanoma-associated antigen 2 is a protein that in humans is encoded by the MAGEA2 gene.

Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene.

Melanoma-associated antigen D2 is a protein that in humans is encoded by the MAGED2 gene.

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.

Melanoma-associated antigen H1 is a protein that in humans is encoded by the MAGEH1 gene.

Melanoma-associated antigen 11 is a protein that in humans is encoded by the MAGEA11 gene. It is also involved in the androgen and progesterone receptor signaling pathways.

Melanoma-associated antigen 12 is a protein that in humans is encoded by the MAGEA12 gene.

Melanoma-associated antigen D4 is a protein that in humans is encoded by the MAGED4B gene.

Melanoma-associated antigen 9 is a protein that in humans is encoded by the MAGEA9 gene.

Melanoma antigen family A, 5 is a protein in humans that is encoded by the MAGEA5 gene.

Melanoma antigen family A, 8 is a protein that in humans is encoded by the MAGEA8 gene.

MAGE family member D4 is a protein that in humans is encoded by the MAGED4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124260 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043453 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MAGE family member A10" . Retrieved 2017-06-15.

Lin J, Lin L, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Barve RA, Weishaar FA, Taylor JM, Orringer MB, Beer DG (2004). "Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants". Clin. Cancer Res. 10 (17): 5708–16. doi:10.1158/1078-0432.CCR-04-0468. PMID 15355897.
Schultz-Thater E, Piscuoglio S, Iezzi G, Le Magnen C, Zajac P, Carafa V, Terracciano L, Tornillo L, Spagnoli GC (2011). "MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies". Int. J. Cancer. 129 (5): 1137–48. doi: 10.1002/ijc.25777 . PMID 21710496.
Badovinac Črnjević T, Tanja BČ, Spagnoli G, Giulio S, Juretić A, Antonio J, Jakić-Razumović J, Jasminka JR, Podolski P, Paula P, Šarić N, Nera Š (2012). "High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer". Med. Oncol. 29 (3): 1586–91. doi:10.1007/s12032-011-0120-9. PMID 22116775. S2CID 22748757.
Wang L, Xu Y, Luo C, Sun J, Zhang J, Lee MW, Bai A, Chen G, Frenz CM, Li Z, Huang W (2015). "MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles". Cell. Immunol. 297 (1): 10–8. doi:10.1016/j.cellimm.2015.05.004. PMID 26058806.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124260 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043453 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MAGE family member A10" . Retrieved 2017-06-15.

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MAGEA10

Contents

Function

Related Research Articles

References

Further reading