MAGED2

MAGED2
Identifiers
Aliases	MAGED2 , 11B6, BCG-1, BCG1, HCA10, MAGE-D2, MAGE family member D2, BARTS5
External IDs	OMIM: 300470; MGI: 1933391; HomoloGene: 12750; GeneCards: MAGED2; OMA:MAGED2 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.21 Start 54,807,599 bp [1] End 54,816,015 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F3 Start 149,589,366 bp [2] End 149,597,341 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary left ovary right ovary ganglionic eminence right uterine tube stromal cell of endometrium Descending thoracic aorta canal of the cervix popliteal artery tibial arteries Top expressed in neural tube placenta Mesencephalon lens genital tubercle ovary tail of embryo adrenal gland yolk sac uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component membrane extracellular region nucleus nucleolus cytosol platelet alpha granule lumen Biological process platelet degranulation female pregnancy renal sodium ion absorption Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10916 80884 Ensembl ENSG00000102316 ENSMUSG00000025268 UniProt Q9UNF1 n/a RefSeq (mRNA) NM_201222 NM_014599 NM_177433 NM_001199246 NM_030700 NM_001358566 NM_001358567 NM_001358568 RefSeq (protein) NP_055414 NP_803182 NP_957516 NP_055414.2 NP_803182.1 NP_957516.1 n/a Location (UCSC) Chr X: 54.81 – 54.82 Mb Chr X: 149.59 – 149.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Melanoma-associated antigen D2 is a protein that in humans is encoded by the MAGED2 gene. ^[5]

This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000102316 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025268 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MAGED2 melanoma antigen family D, 2".

Further reading

• Lucas S, Brasseur F, Boon T (1999). "A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells". Cancer Res. 59 (16): 4100–3. PMID   10463614.
• Kurt RA, Urba WJ, Schoof DD (2000). "Isolation of genes overexpressed in freshly isolated breast cancer specimens". Breast Cancer Res. Treat. 59 (1): 41–8. doi:10.1023/A:1006315919985. PMID   10752678. S2CID   22929402.
• Langnaese K, Kloos DU, Wehnert M, et al. (2002). "Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues". Cytogenet. Cell Genet. 94 (3–4): 233–40. doi:10.1159/000048822. PMID   11856887. S2CID   44297066.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bertrand M, Huijbers I, Chomez P, De Backer O (2005). "Comparative expression analysis of the MAGED genes during embryogenesis and brain development". Dev. Dyn. 230 (2): 325–34. doi: 10.1002/dvdy.20026 . PMID   15162511.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Harper R, Xu C, Di P, et al. (2004). "Identification of a novel MAGE D2 antisense RNA transcript in human tissues". Biochem. Biophys. Res. Commun. 324 (1): 199–204. doi:10.1016/j.bbrc.2004.09.037. PMID   15465002.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Papageorgio C, Brachmann R, Zeng J, et al. (2007). "MAGED2: a novel p53-dissociator". Int. J. Oncol. 31 (5): 1205–11. doi: 10.3892/ijo.31.5.1205 . PMID   17912449.