MAGED4B

MAGED4B
Identifiers
Aliases	MAGED4B , MAGE family member D4B
External IDs	OMIM: 300765 HomoloGene: 52232 GeneCards: MAGED4B
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.22 Start 52,061,827 bp [1] End 52,069,219 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence pituitary gland hypothalamus anterior pituitary nucleus accumbens amygdala caudate nucleus putamen hippocampus proper substantia nigra n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 81557 n/a Ensembl ENSG00000187243 n/a UniProt Q96JG8 n/a RefSeq (mRNA) NM_001242362 NM_030801 NM_177535 NM_177537 n/a RefSeq (protein) NP_001092270 NP_001258990 NP_001258991 NP_001258992 n/a Location (UCSC) Chr X: 52.06 – 52.07 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Melanoma-associated antigen D4 is a protein that in humans is encoded by the MAGED4B gene. ^[3]

This gene is related to members of the MAGED gene family, in terms of the sequence similarity and the chromosome location. This gene is expressed only in brain and ovary among normal tissues, and two transcript variants of this gene are specifically expressed in glioma cells among cancer cells. This gene and the other MAGED genes are clustered on chromosome Xp11. Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined. ^[3]

References

1. GRCh38: Ensembl release 89: ENSG00000187243 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "MAGED4B MAGE family member D4B [Homo sapiens (human)]". National Center for Biotechnology Information . Retrieved 28 September 2020.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi: 10.1093/dnares/8.2.85 . PMID   11347906.
• Sasaki M, Nakahira K, Kawano Y, et al. (2001). "MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma". Cancer Res. 61 (12): 4809–14. PMID   11406556.
• Kawano Y, Sasaki M, Nakahira K, et al. (2001). "Structural characterization and chromosomal localization of the MAGE-E1 gene". Gene. 277 (1–2): 129–37. doi:10.1016/S0378-1119(01)00698-9. hdl: 2433/149322 . PMID   11602350. S2CID   19474178.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ito S, Kawano Y, Katakura H, et al. (2006). "Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer". Lung Cancer. 51 (1): 79–88. doi:10.1016/j.lungcan.2005.08.012. hdl: 2433/143846 . PMID   16225959.