MAK (gene)

MAK
Identifiers
Aliases	MAK , RP62, dJ417M14.2, male germ cell associated kinase
External IDs	OMIM: 154235 MGI: 96913 HomoloGene: 31344 GeneCards: MAK
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p24.2 Start 10,762,723 bp [1] End 10,838,553 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 A3.3|13 20.25 cM Start 41,178,484 bp [2] End 41,233,182 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm bronchial epithelial cell right uterine tube blood caput epididymis secondary oocyte monocyte palpebral conjunctiva Achilles tendon cerebellar vermis Top expressed in spermatid seminiferous tubule spermatocyte retinal pigment epithelium outer nuclear layer right lung lobe respiratory epithelium olfactory epithelium pineal gland utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding transcription coactivator activity kinase activity protein binding ATP binding metal ion binding protein serine/threonine kinase activity Cellular component centrosome cell projection photoreceptor inner segment spindle photoreceptor outer segment microtubule organizing center midbody mitotic spindle cytoskeleton nucleus cytoplasm cilium axoneme motile cilium photoreceptor connecting cilium ciliary tip Biological process cell differentiation regulation of transcription, DNA-templated phosphorylation transcription, DNA-templated multicellular organism development protein phosphorylation spermatogenesis protein autophosphorylation regulation of gene expression intracellular signal transduction intraciliary transport cilium assembly photoreceptor cell maintenance negative regulation of non-motile cilium assembly positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4117 17152 Ensembl ENSG00000111837 ENSMUSG00000021363 UniProt P20794 Q04859 RefSeq (mRNA) NM_001242385 NM_001242957 NM_005906 NM_001377262 NM_001145802 NM_001145803 NM_008547 RefSeq (protein) NP_001229314 NP_001229886 NP_005897 NP_001364191 NP_001139274 NP_001139275 NP_032573 Location (UCSC) Chr 6: 10.76 – 10.84 Mb Chr 13: 41.18 – 41.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase MAK is an enzyme that in humans is encoded by the MAK gene. ^{[5] [6]}

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000111837 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021363 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, Shih HM, Shi XB, deVere White RW, Chen HW, Tepper CG, Kung HJ (Sep 2006). "Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells". Cancer Res. 66 (17): 8439–47. doi:10.1158/0008-5472.CAN-06-1636. PMID   16951154.
6. "Entrez Gene: MAK male germ cell-associated kinase".

Further reading

• Koji T, Jinno A, Matsushime H, et al. (1993). "In situ localization of male germ cell-associated kinase (mak) mRNA in adult mouse testis: specific expression in germ cells at stages around meiotic cell division". Cell Biochem. Funct. 10 (4): 273–9. doi:10.1002/cbf.290100411. PMID   1473268. S2CID   5717763.
• Matsushime H, Jinno A, Takagi N, Shibuya M (1990). "A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis". Mol. Cell. Biol. 10 (5): 2261–8. doi:10.1128/MCB.10.5.2261. PMC   360573 . PMID   2183027.
• Taketo M, Jinno A, Yamaguchi S, et al. (1994). "Mouse Mak gene for male germ cell-associated kinase maps to chromosome 13". Genomics. 19 (2): 397–8. doi:10.1006/geno.1994.1082. PMID   8188277.
• Jinno A, Tanaka K, Matsushime H, et al. (1993). "Testis-specific mak protein kinase is expressed specifically in the meiotic phase in spermatogenesis and is associated with a 210-kilodalton cellular phosphoprotein". Mol. Cell. Biol. 13 (7): 4146–56. doi:10.1128/MCB.13.7.4146. PMC   359964 . PMID   8321219.
• Bladt F, Birchmeier C (1993). "Characterization and expression analysis of the murine rck gene: a protein kinase with a potential function in sensory cells". Differentiation. 53 (2): 115–22. doi:10.1111/j.1432-0436.1993.tb00651.x. PMID   8359591.
• Xia L, Robinson D, Ma AH, et al. (2002). "Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells". J. Biol. Chem. 277 (38): 35422–33. doi: 10.1074/jbc.M203940200 . PMID   12084720.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Fu Z, Larson KA, Chitta RK, et al. (2007). "Identification of Yin-Yang Regulators and a Phosphorylation Consensus for Male Germ Cell-Associated Kinase (MAK)-Related Kinase". Mol. Cell. Biol. 26 (22): 8639–54. doi:10.1128/MCB.00816-06. PMC   1636783 . PMID   16954377.