MALL

MALL
Identifiers
Aliases	MALL , BENE, mal, T-cell differentiation protein like, mal, T cell differentiation protein like
External IDs	OMIM: 602022; MGI: 2385152; HomoloGene: 3965; GeneCards: MALL; OMA:MALL - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q13 Start 110,083,870 bp [1] End 110,116,022 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 F1 Start 127,546,306 bp [2] End 127,571,852 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum mucosa of transverse colon epithelium of bronchus rectum vagina skin of leg upper lobe of left lung skin of abdomen islet of Langerhans tonsil Top expressed in esophagus intestinal villus duodenum ileum jejunum lip conjunctival fornix large intestine colon left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of myelin sheath Cellular component Golgi membrane clathrin-coated vesicle plasma membrane membrane membrane raft integral component of membrane cytoplasmic vesicle Biological process cholesterol homeostasis membrane raft polarization protein localization myelination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7851 228576 Ensembl ENSG00000144063 ENSMUSG00000027377 UniProt Q13021 Q91X49 RefSeq (mRNA) NM_005434 NM_001371559 NM_001371560 NM_145532 RefSeq (protein) NP_005425 NP_001358488 NP_001358489 NP_663507 Location (UCSC) Chr 2: 110.08 – 110.12 Mb Chr 2: 127.55 – 127.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

For other uses, see Mall.

MAL-like protein is a protein that in humans is encoded by the MALL gene. ^{[5] [6]}

This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid-enriched membrane (GEM) and cholesterol-enriched membrane rafts. It interacts with caveolin-1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000144063 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027377 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hildebrandt F, Otto E, Rensing C, Nothwang HG, Vollmer M, Adolphs J, Hanusch H, Brandis M (Nov 1997). "A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1". Nat Genet. 17 (2): 149–53. doi:10.1038/ng1097-149. PMID   9326933. S2CID   38035697.
6. "Entrez Gene: MALL mal, T-cell differentiation protein-like".

Further reading

• Kurdina MI, Denisov LE (1993). "[An evaluation of the efficacy of dispensary care as a method for the active detection of skin melanoma]". Klinicheskaia Meditsina. 70 (11–12): 68–70. PMID   1294831.
• Lautner-Rieske A, Thiebe R, Zachau HG (1995). "Searching for non-V kappa transcripts from the human immunoglobulin kappa locus". Gene. 159 (2): 199–202. doi:10.1016/0378-1119(95)00161-X. PMID   7622049.
• Magyar JP, Ebensperger C, Schaeren-Wiemers N, Suter U (1997). "Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family". Gene. 189 (2): 269–75. doi:10.1016/S0378-1119(96)00861-X. PMID   9168137.
• Saunier S, Calado J, Heilig R, et al. (1998). "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis". Hum. Mol. Genet. 6 (13): 2317–23. doi: 10.1093/hmg/6.13.2317 . PMID   9361039.
• de Marco MC, Kremer L, Albar JP, et al. (2001). "BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells". J. Biol. Chem. 276 (25): 23009–17. doi: 10.1074/jbc.M009739200 . PMID   11294831.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.