MAN1A1

MAN1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NXC
Identifiers
Aliases	MAN1A1 , HUMM3, HUMM9, MAN9, mannosidase alpha class 1A member 1
External IDs	OMIM: 604344; MGI: 104677; HomoloGene: 4316; GeneCards: MAN1A1; OMA:MAN1A1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q22.31 Start 119,177,205 bp [1] End 119,349,761 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 B3 Start 53,780,881 bp [2] End 53,952,705 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint renal medulla pericardium jejunal mucosa lower lobe of lung urethra parotid gland palpebral conjunctiva Achilles tendon skin of hip Top expressed in parotid gland mesenteric lymph nodes lateral septal nucleus vestibular membrane of cochlear duct retinal pigment epithelium lacrimal gland epithelium of stomach otic placode submandibular gland spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding hydrolase activity mannosidase activity hydrolase activity, acting on glycosyl bonds mannosyl-oligosaccharide 1,2-alpha-mannosidase activity catalytic activity Cellular component integral component of membrane Golgi membrane Golgi apparatus extracellular exosome endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment cytosol Biological process protein glycosylation N-glycan processing metabolism Golgi apparatus mannose trimming Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4121 17155 Ensembl ENSG00000111885 ENSMUSG00000003746 UniProt P33908 P45700 RefSeq (mRNA) NM_005907 NM_008548 RefSeq (protein) NP_005898 NP_032574 Location (UCSC) Chr 6: 119.18 – 119.35 Mb Chr 10: 53.78 – 53.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene. ^{[5] [6]}

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the removal of 3 distinct mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000111885 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003746 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bause E, Bieberich E, Rolfs A, Volker C, Schmidt B (Dec 1993). "Molecular cloning and primary structure of Man9-mannosidase from human kidney". Eur J Biochem. 217 (2): 535–40. doi: 10.1111/j.1432-1033.1993.tb18274.x . PMID   8223597.
6. "Entrez Gene: MAN1A1 mannosidase, alpha, class 1A, member 1".

Further reading

• Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–90. doi:10.1016/S0300-9084(01)01314-1. hdl: 1874/5091 . PMID   11530211. S2CID   13576808.
• Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–82. doi:10.1016/0042-6822(92)90331-I. PMID   1736542.
• Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID   2187500.
• Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi: 10.7883/yoken1952.43.75 . PMID   2283726.
• Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". J. Biol. Chem. 265 (18): 10373–82. doi: 10.1016/S0021-9258(18)86956-3 . PMID   2355006.
• Stein BS, Engleman EG (1990). "Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex". J. Biol. Chem. 265 (5): 2640–9. doi: 10.1016/S0021-9258(19)39849-7 . PMID   2406237.
• Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi: 10.1073/pnas.86.9.3384 . PMC   287137 . PMID   2541446.
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. doi:10.1128/JVI.63.6.2452-2456.1989. PMC   250699 . PMID   2542563.
• Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID   2649653.
• Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID   2829950.
• Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID   3099781.
• Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi: 10.1073/pnas.85.23.9248 . PMC   282716 . PMID   3264072.
• Bieberich E, Bause E (1995). "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein". Eur. J. Biochem. 233 (2): 644–9. doi: 10.1111/j.1432-1033.1995.644_2.x . PMID   7588811.
• Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/JVI.67.1.150-160.1993. PMC   237347 . PMID   8093218.
• Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID   8218172.
• Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi: 10.1097/00042560-199607000-00001 . PMID   8673525.
• Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/JVI.70.11.7462-7470.1996. PMC   190813 . PMID   8892864.
• Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. doi: 10.1016/S0014-5793(97)00273-1 . PMID   9109416. S2CID   17660.
• Bieberich E, Treml K, Völker C, et al. (1997). "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells". Eur. J. Biochem. 246 (3): 681–9. doi: 10.1111/j.1432-1033.1997.t01-1-00681.x . PMID   9219526.