MAP4K3

MAP4K3
Identifiers
Aliases	MAP4K3 , GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1, mitogen-activated protein kinase kinase kinase kinase 3
External IDs	OMIM: 604921 MGI: 2154405 HomoloGene: 2683 GeneCards: MAP4K3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	39,437,301 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	80,728,485 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; sural nerve; ; tibia; ; gastrocnemius muscle; ; biceps brachii; ; endometrium; ; jejunum; ; jejunal mucosa; ; palpebral conjunctiva;
	Top expressed in
	Paneth cell; ; left lung lobe; ; retina; ; calvaria; ; Region I of hippocampus proper; ; fossa; ; cingulate gyrus; ; iris; ; condyle; ; right lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; protein kinase activity ; protein serine/threonine kinase activity ; nucleotide binding ; protein binding ; ATP binding ; kinase activity ; MAP kinase kinase kinase kinase activity ;
Cellular component	cytoplasm ;
Biological process	response to tumor necrosis factor ; protein phosphorylation ; JNK cascade ; intracellular signal transduction ; response to UV ; phosphorylation ; regulation of mitotic cell cycle ; regulation of apoptotic process ; signal transduction ; stress-activated protein kinase signaling cascade ; activation of protein kinase activity ;
	Sources:Amigo / QuickGO
Orthologs
	8491
	225028
	ENSG00000011566
	ENSMUSG00000024242
	Q8IVH8
	Q99JP0
	NM_001270425 ; NM_003618
	NM_001081357 ; NM_001290345 ; NM_001360278
	NP_001257354 ; NP_003609
	NP_001277274 ; NP_001347207
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Mitogen-activated protein kinase kinase kinase kinase 3 is a protein that in humans is encoded by the MAP4K3 gene. ^[5]

Function

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Related Research Articles

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.

Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene.

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1. The protein has been shown to play a role in JNK activation.

Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene.

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.

Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene.

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene.

MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.

<span class="mw-page-title-main">DUSP4</span> Protein-coding gene in the species Homo sapiens

Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.

Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.

Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 gene.

Mitogen-activated protein kinase 12, also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.

Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000011566 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024242 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Mitogen-activated protein kinase kinase kinase kinase 3" . Retrieved 2017-09-22.

Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, Martins LM (2009). "MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins". Proc. Natl. Acad. Sci. U.S.A. 106 (29): 11978–83. Bibcode:2009PNAS..10611978L. doi: 10.1073/pnas.0900608106 . PMC 2707271 . PMID 19587239.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.
Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, Foroud T, Econs MJ (2010). "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women". J. Bone Miner. Res. 25 (8): 1821–9. doi:10.1002/jbmr.62. PMC 3153352 . PMID 20200978.
Yan L, Mieulet V, Burgess D, Findlay GM, Sully K, Procter J, Goris J, Janssens V, Morrice NA, Lamb RF (2010). "PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR". Mol. Cell. 37 (5): 633–42. doi: 10.1016/j.molcel.2010.01.031 . PMID 20227368.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168 . PMID 20628086.
Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH (2011). "The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells". Nat. Immunol. 12 (11): 1113–8. doi:10.1038/ni.2121. PMID 21983831. S2CID 205364658.
Chen DY, Chuang HC, Lan JL, Chen YM, Hung WT, Lai KL, Tan TH (2012). "Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker". BMC Med. 10: 84. doi: 10.1186/1741-7015-10-84 . PMC 3424974 . PMID 22867055.
Schriever SC, Deutsch MJ, Adamski J, Roscher AA, Ensenauer R (2013). "Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism". J. Nutr. Biochem. 24 (5): 824–31. doi:10.1016/j.jnutbio.2012.04.018. PMID 22898570.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000011566 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024242 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mitogen-activated protein kinase kinase kinase kinase 3" . Retrieved 2017-09-22.

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MAP4K3

Contents

Function

Related Research Articles

References

Further reading