MAPK8IP1

MAPK8IP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G01, 2GMX, 2H96, 3OXI, 3PTG, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4E73, 4G1W, 4H39, 4HYS, 4HYU, 4IZY
Identifiers
Aliases	MAPK8IP1 , IB1, JIP-1, JIP1, PRKM8IP, mitogen-activated protein kinase 8 interacting protein 1
External IDs	OMIM: 604641 MGI: 1309464 HomoloGene: 31314 GeneCards: MAPK8IP1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 45,885,651 bp [1] End 45,906,465 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 92,214,021 bp [2] End 92,231,608 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary tibial nerve prefrontal cortex Brodmann area 9 Brodmann area 10 amygdala middle frontal gyrus ganglionic eminence sural nerve nucleus accumbens Top expressed in superior frontal gyrus entorhinal cortex cerebellar cortex superior surface of tongue gallbladder dorsomedial hypothalamic nucleus cingulate gyrus primary motor cortex lateral geniculate nucleus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MAP-kinase scaffold activity protein kinase inhibitor activity protein binding kinesin binding protein kinase binding JUN kinase binding mitogen-activated protein kinase kinase binding mitogen-activated protein kinase kinase kinase binding Cellular component cytoplasm cell body cytosol dendritic growth cone endoplasmic reticulum membrane mitochondrial membrane membrane dentate gyrus mossy fiber axonal growth cone synapse axon dendrite endoplasmic reticulum mitochondrion perinuclear region of cytoplasm neuron projection nucleus plasma membrane Biological process regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process negative regulation of JNK cascade regulation of JNK cascade JUN phosphorylation negative regulation of JUN kinase activity vesicle-mediated transport signal transduction positive regulation of MAPK cascade positive regulation of JNK cascade regulation of CD8-positive, alpha-beta T cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9479 19099 Ensembl ENSG00000121653 ENSMUSG00000027223 UniProt Q9UQF2 Q9WVI9 RefSeq (mRNA) NM_005456 NM_001202445 NM_001202446 NM_011162 RefSeq (protein) NP_005447 NP_001189374 NP_001189375 NP_035292 Location (UCSC) Chr 11: 45.89 – 45.91 Mb Chr 2: 92.21 – 92.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene. ^{[5] [6]}

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. ^[7]

Interactions

MAPK8IP1 has been shown to interact with MAP3K10, ^[8] DUSP16, ^[9] Mitogen-activated protein kinase 9, ^{[8] [10]} MAPK8, ^{[10] [11]} LRP2, ^{[12] [13]} LRP1, ^[12] MAP3K12, ^[8] MAP2K7, ^[8] MAPK8IP2 ^[8] and MAP3K11. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000121653 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027223 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ (August 1997). "A cytoplasmic inhibitor of the JNK signal transduction pathway". Science. 277 (5326): 693–6. doi: 10.1126/science.277.5326.693 . PMID   9235893.
6. Bonny C, Nicod P, Waeber G (March 1998). "IB1, a JIP-1-related nuclear protein present in insulin-secreting cells". J Biol Chem. 273 (4): 1843–6. doi: 10.1074/jbc.273.4.1843 . PMID   9442013.
7. "Entrez Gene: MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1".
8. Yasuda J, Whitmarsh A J, Cavanagh J, Sharma M, Davis R J (October 1999). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. ISSN   0270-7306. PMC   84717 . PMID   10490659.
9. Willoughby EA, Perkins Gordon R, Collins Mary K, Whitmarsh Alan J (March 2003). "The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK". J. Biol. Chem. 278 (12): 10731–6. doi: 10.1074/jbc.M207324200 . ISSN   0021-9258. PMID   12524447.
10. Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis R J (September 1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science . 281 (5383): 1671–4. Bibcode:1998Sci...281.1671W. doi:10.1126/science.281.5383.1671. ISSN   0036-8075. PMID   9733513.
11. Cai Y, Lechner Mark S, Nihalani Deepak, Prindle Marc J, Holzman Lawrence B, Dressler Gregory R (January 2002). "Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation". J. Biol. Chem. 277 (2): 1217–22. doi: 10.1074/jbc.M109663200 . ISSN   0021-9258. PMID   11700324.
12. Gotthardt M, Trommsdorff M, Nevitt M F, Shelton J, Richardson J A, Stockinger W, Nimpf J, Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi: 10.1074/jbc.M000955200 . ISSN   0021-9258. PMID   10827173.
13. Petersen HH, Hilpert Jan, Militz Daniel, Zandler Valerie, Jacobsen Christian, Roebroek Anton J M, Willnow Thomas E (February 2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. doi: 10.1242/jcs.00243 . ISSN   0021-9533. PMID   12508107.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Whitmarsh AJ, Cavanagh J, Tournier C, et al. (1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science. 281 (5383): 1671–4. Bibcode:1998Sci...281.1671W. doi:10.1126/science.281.5383.1671. PMID   9733513.
• Mooser V, Maillard A, Bonny C, et al. (1999). "Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun –amino-terminal kinase interacting protein-1 (JIP-1) gene". Genomics. 55 (2): 202–8. doi:10.1006/geno.1998.5641. PMID   9933567.
• Yasuda J, Whitmarsh AJ, Cavanagh J, et al. (2000). "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC   84717 . PMID   10490659.
• Meyer D, Liu A, Margolis B (2000). "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons". J. Biol. Chem. 274 (49): 35113–8. doi: 10.1074/jbc.274.49.35113 . PMID   10574993.
• Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. PMC   85220 . PMID   10629060.
• Waeber G, Delplanque J, Bonny C, et al. (2000). "The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes". Nat. Genet. 24 (3): 291–5. doi:10.1038/73523. PMID   10700186. S2CID   5964917.
• Bonny C, Oberson A, Steinmann M, et al. (2000). "IB1 reduces cytokine-induced apoptosis of insulin-secreting cells". J. Biol. Chem. 275 (22): 16466–72. doi: 10.1074/jbc.M908297199 . PMID   10748095.
• Gotthardt M, Trommsdorff M, Nevitt MF, et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi: 10.1074/jbc.M000955200 . PMID   10827173.
• Bonny C, Oberson A, Negri S, et al. (2001). "Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death". Diabetes. 50 (1): 77–82. doi: 10.2337/diabetes.50.1.77 . PMID   11147798.
• Verhey KJ, Meyer D, Deehan R, et al. (2001). "Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules". J. Cell Biol. 152 (5): 959–70. doi:10.1083/jcb.152.5.959. PMC   2198804 . PMID   11238452.
• Matsuda S, Yasukawa T, Homma Y, et al. (2001). "c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK". J. Neurosci. 21 (17): 6597–607. doi: 10.1523/JNEUROSCI.21-17-06597.2001 . PMC   6763068 . PMID   11517249.
• Abderrahmani A, Steinmann M, Plaisance V, et al. (2001). "The Transcriptional Repressor REST Determines the Cell-Specific Expression of the Human MAPK8IP1 Gene Encoding IB1 (JIP-1)". Mol. Cell. Biol. 21 (21): 7256–67. doi:10.1128/MCB.21.21.7256-7267.2001. PMC   99900 . PMID   11585908.
• Cai Y, Lechner MS, Nihalani D, et al. (2002). "Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation". J. Biol. Chem. 277 (2): 1217–22. doi: 10.1074/jbc.M109663200 . PMID   11700324.
• Scheinfeld MH, Roncarati R, Vito P, et al. (2002). "Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP)". J. Biol. Chem. 277 (5): 3767–75. doi: 10.1074/jbc.M108357200 . PMID   11724784.
• Ikeda A, Hasegawa K, Masaki M, et al. (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem. 130 (6): 773–81. doi:10.1093/oxfordjournals.jbchem.a003048. PMID   11726277.
• Hashimoto M, Hsu LJ, Rockenstein E, et al. (2002). "alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells". J. Biol. Chem. 277 (13): 11465–72. doi: 10.1074/jbc.M111428200 . PMID   11790792.