MAPKAP1

Last updated
MAPKAP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPKAP1 , JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1, MAPK associated protein 1
External IDs OMIM: 610558 MGI: 2444554 HomoloGene: 11473 GeneCards: MAPKAP1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 9: 125.44 – 125.71 Mb Chr 2: 34.41 – 34.62 Mb
PubMed search [3] [4]
Wikidata
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Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene. [5] [6] As the name indicates, it is a subunit of mTOR complex 2.

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119487 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038696 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schroder W, Cloonan N, Bushell G, et al. (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene. 339: 17–23. doi:10.1016/j.gene.2004.07.001. PMID   15363842.
  6. 1 2 "Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1".

Further reading