MARS Bioimaging

Last updated

MARS Bioimaging
Industry Health care
Radiology
Manufacturing
FoundedSeptember 2007
FounderPhilip Butler, Anthony Butler
Headquarters,
Area served
Worldwide
Key people
Philip Butler, CEO
Products CT, spectral photon-counting CT
Services Medical equipment
Technology for drug discovery and biopharmaceuticals
Solutions for clinicians and health care administrators
Website www.marsbioimaging.com

MARS Bioimaging Limited (MBI) is a medical imaging company focusing on spectral photon counting computed tomography for quantitative color imaging. [1] The company was founded in Christchurch, New Zealand to commercialize the MARS imaging system for its applications in medicine.

History

MARS Bioimaging Limited was founded in September 2007 [2] by father and son professors, Phillip and Anthony Butler to develop x-ray imaging that captures and processes information from individual x-ray photons, producing quantitative 3D color imaging at very high resolution (50-200 μm). [3] [4] [5] MARS imaging systems are based on the new generation Medipix chip licensed out of CERN (European Organization for Nuclear Research), Switzerland [2] and technology developed by the University of Canterbury (UC), and other partners. [6]

Funding for research began in 2003, with a NZ$500,000 grant from the New Economy Research Fund. This fund enabled New Zealand universities to join CERN, including .

NZ$1.5 million grant from the Tertiary Education Commission - Infrastructure Development Fund was awarded to MBI after forming in 2007, followed by a NZ$4.5 million manufacturing award from the Foundation for Research Science and Technology to developing a small animal spectral scanner for researchers.

In 2011, MBI released its first small-bore spectral CT scanner for CT researchers [7] and remains the only company in the world with a commercially available preclinical spectral photon-counting CT scanner. [8]

In February 2014, MBI raised more than NZ$500,000 in series A capital financing led by Powerhouse Ventures (PowerHouse). [7] Series B funding in March 2015, again led by PowerHouse Ventures, raised another NZ$500,000. [9]

The Ministry of Business, Innovation and Employment (MBIE) awarded MBI a High Value Manufacturing award, worth NZ$13 million over 2014-2021.

Since October 2015, Callaghan Innovations has supported MBI in employing MARS researchers through a number of Research and Development Career Grants. [9]

In November 2018, the CEO of MBI was the first living human scanned by a MARS system, [10] followed by the first patient scanned early 2020. [1] On November 16, 2020, MBI announced international clinical trials of their compact, point-of-care MARS system for diagnosing hand and wrist injuries would begin early 2021. [1]

Related Research Articles

<span class="mw-page-title-main">Positron emission tomography</span> Medical imaging technique

Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body.

<span class="mw-page-title-main">CT scan</span> Medical imaging procedure using X-rays to produce cross-sectional images

A computed tomography scan is a medical imaging technique used to obtain detailed internal images of the body. The personnel that perform CT scans are called radiographers or radiology technologists.

<span class="mw-page-title-main">DESY</span> German national research center

DESY, short for Deutsches Elektronen-Synchrotron, is a national research centre for fundamental science located in Hamburg and Zeuthen near Berlin in Germany. It operates particle accelerators used to investigate the structure, dynamics and function of matter, and conducts a broad spectrum of interdisciplinary scientific research in four main areas: particle and high energy physics; photon science; astroparticle physics; and the development, construction and operation of particle accelerators. Its name refers to its first project, an electron synchrotron. DESY is publicly financed by the Federal Republic of Germany and the Federal States of Hamburg and Brandenburg and is a member of the Helmholtz Association.

<span class="mw-page-title-main">Medical imaging</span> Technique and process of creating visual representations of the interior of a body

Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organs and tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging.

<span class="mw-page-title-main">Single-photon emission computed tomography</span> Nuclear medicine tomographic imaging technique

Single-photon emission computed tomography is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera, but is able to provide true 3D information. This information is typically presented as cross-sectional slices through the patient, but can be freely reformatted or manipulated as required.

<span class="mw-page-title-main">Tomography</span> Imaging by sections or sectioning using a penetrative wave

Tomography is imaging by sections or sectioning that uses any kind of penetrating wave. The method is used in radiology, archaeology, biology, atmospheric science, geophysics, oceanography, plasma physics, materials science, cosmochemistry, astrophysics, quantum information, and other areas of science. The word tomography is derived from Ancient Greek τόμος tomos, "slice, section" and γράφω graphō, "to write" or, in this context as well, "to describe." A device used in tomography is called a tomograph, while the image produced is a tomogram.

<span class="mw-page-title-main">Electron beam computed tomography</span> Medical diagnostic technology

Electron beam computed tomography (EBCT) is a specific form of computed tomography (CT) in which the X-ray tube is not mechanically spun in order to rotate the source of X-ray photons. This different design was explicitly developed to better image heart structures that never stop moving, performing a complete cycle of movement with each heartbeat.

Nanotomography, much like its related modalities tomography and microtomography, uses x-rays to create cross-sections from a 3D-object that later can be used to recreate a virtual model without destroying the original model, applying Nondestructive testing. The term nano is used to indicate that the pixel sizes of the cross-sections are in the nanometer range

<span class="mw-page-title-main">3D scanning</span> Scanning of an object or environment to collect data on its shape

3D scanning is the process of analyzing a real-world object or environment to collect three dimensional data of its shape and possibly its appearance. The collected data can then be used to construct digital 3D models.

<span class="mw-page-title-main">Full body scanner</span> Device which detects objects in or around a persons body

A full-body scanner is a device that detects objects on or inside a person's body for security screening purposes, without physically removing clothes or making physical contact. Unlike metal detectors, full-body scanners can detect non-metal objects, which became an increasing concern after various airliner bombing attempts in the 2000s. Some scanners can also detect swallowed items or hidden in body cavities of a person. Starting in 2007, full-body scanners started supplementing metal detectors at airports and train stations in many countries.

<span class="mw-page-title-main">Medipix</span> Family of pixel detectors

Medipix is a family of photon counting and particle tracking pixel detectors developed by an international collaboration, hosted by CERN.

<span class="mw-page-title-main">PET-CT</span> Medical imaging method

Positron emission tomography–computed tomography is a nuclear medicine technique which combines, in a single gantry, a positron emission tomography (PET) scanner and an x-ray computed tomography (CT) scanner, to acquire sequential images from both devices in the same session, which are combined into a single superposed (co-registered) image. Thus, functional imaging obtained by PET, which depicts the spatial distribution of metabolic or biochemical activity in the body can be more precisely aligned or correlated with anatomic imaging obtained by CT scanning. Two- and three-dimensional image reconstruction may be rendered as a function of a common software and control system.

<span class="mw-page-title-main">Industrial computed tomography</span> Computer-aided tomographic process

Industrial computed tomography (CT) scanning is any computer-aided tomographic process, usually X-ray computed tomography, that uses irradiation to produce three-dimensional internal and external representations of a scanned object. Industrial CT scanning has been used in many areas of industry for internal inspection of components. Some of the key uses for industrial CT scanning have been flaw detection, failure analysis, metrology, assembly analysis and reverse engineering applications. Just as in medical imaging, industrial imaging includes both nontomographic radiography and computed tomographic radiography.

<span class="mw-page-title-main">Cone beam computed tomography</span> Medical imaging technique

Cone beam computed tomography is a medical imaging technique consisting of X-ray computed tomography where the X-rays are divergent, forming a cone.

<span class="mw-page-title-main">Photon counting</span> Counting photons using a single-photon detector

Photon counting is a technique in which individual photons are counted using a single-photon detector (SPD). A single-photon detector emits a pulse of signal for each detected photon. The counting efficiency is determined by the quantum efficiency and the system's electronic losses.

Photon-counting computed tomography (PCCT) is a form of X-ray computed tomography (CT) in which X-rays are detected using a photon-counting detector (PCD) which registers the interactions of individual photons. By keeping track of the deposited energy in each interaction, the detector pixels of a PCD each record an approximate energy spectrum, making it a spectral or energy-resolved CT technique. In contrast, more conventional CT scanners use energy-integrating detectors (EIDs), where the total energy deposited in a pixel during a fixed period of time is registered. These EIDs thus register only photon intensity, comparable to black-and-white photography, whereas PCDs register also spectral information, similar to color photography.

<span class="mw-page-title-main">History of computed tomography</span> History of CT scanning technology

The history of X-ray computed tomography dates back to at least 1917 with the mathematical theory of the Radon transform In October 1963, William H. Oldendorf received a U.S. patent for a "radiant energy apparatus for investigating selected areas of interior objects obscured by dense material". The first clinical CT scan was performed in 1971 using a scanner invented by Sir Godfrey Hounsfield.

Hybrid pixel detectors are a type of ionizing radiation detector consisting of an array of diodes based on semiconductor technology and their associated electronics. The term “hybrid” stems from the fact that the two main elements from which these devices are built, the semiconductor sensor and the readout chip, are manufactured independently and later electrically coupled by means of a bump-bonding process. Ionizing particles are detected as they produce electron-hole pairs through their interaction with the sensor element, usually made of doped silicon or cadmium telluride. The readout ASIC is segmented into pixels containing the necessary electronics to amplify and measure the electrical signals induced by the incoming particles in the sensor layer.

Spectral imaging is an umbrella term for energy-resolved X-ray imaging in medicine. The technique makes use of the energy dependence of X-ray attenuation to either increase the contrast-to-noise ratio, or to provide quantitative image data and reduce image artefacts by so-called material decomposition. Dual-energy imaging, i.e. imaging at two energy levels, is a special case of spectral imaging and is still the most widely used terminology, but the terms "spectral imaging" and "spectral CT" have been coined to acknowledge the fact that photon-counting detectors have the potential for measurements at a larger number of energy levels.

4DMedical is a medical technology company, based in Australia and the United States.

References

  1. 1 2 3 "New 3D colour X-rays made possible with CERN technology". CERN. Retrieved 30 November 2020.
  2. 1 2 "Medipix: From particles to patients". CERN. Retrieved 30 November 2020.
  3. "Kiwi scientists revolutionising x-ray scanning technology | Ministry of Business, Innovation & Employment". www.mbie.govt.nz. Retrieved 30 November 2020.
  4. "2018 News Items". Website. Retrieved 30 November 2020.
  5. Walsh, M F; Opie, A M T; Ronaldson, J P; Doesburg, R M N; Nik, S J; Mohr, J L; Ballabriga, R; Butler, A P H; Butler, P H (21 January 2011). "First CT using Medipix3 and the MARS-CT-3 spectral scanner". Journal of Instrumentation. 6 (1): C01095. Bibcode:2011JInst...6.1095W. doi: 10.1088/1748-0221/6/01/c01095 . ISSN   1748-0221. S2CID   250678034.
  6. Schioppa, Enrico Junior; Visser, Jan; Koffeman, Els (3 July 2015). "Prospects for spectral CT with Medipix detectors". Proceedings of Technology and Instrumentation in Particle Physics 2014 — PoS(TIPP2014). Trieste, Italy: Sissa Medialab: 246. doi: 10.22323/1.213.0246 .
  7. 1 2 "MARS Bioimaging to Position Itself for Series A Fundraising". www.scoop.co.nz. 25 February 2014. Retrieved 30 November 2020.
  8. Holbrook, M.; Clark, D. P.; Barber, W.; Badea, C. T. (9 March 2018). "Development of a spectral photon-counting micro-CT system with a translate-rotate geometry". In Gilat Schmidt, Taly; Lo, Joseph Y; Chen, Guang-Hong (eds.). Medical Imaging 2018: Physics of Medical Imaging. Vol. 10573. International Society for Optics and Photonics. pp. 105731D. Bibcode:2018SPIE10573E..1DH. doi:10.1117/12.2293373. ISBN   9781510616356. S2CID   125776399.
  9. 1 2 "MARS Bioimaging". Scale-Up New Zealand. Retrieved 30 November 2020.
  10. "First 3D colour X-ray of a human using CERN technology". CERN. Retrieved 30 November 2020.