MAZ (gene)

MAZ
Identifiers
Aliases	MAZ , PUR1, Pur-1, SAF-1, SAF-2, SAF-3, ZF87, ZNF801, Zif87, MYC associated zinc finger protein
External IDs	OMIM: 600999 MGI: 1338823 HomoloGene: 106451 GeneCards: MAZ
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 29,806,106 bp [1] End 29,811,164 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 126,621,302 bp [2] End 126,626,209 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence stromal cell of endometrium right coronary artery amygdala rectum lymph node canal of the cervix right lobe of thyroid gland left uterine tube right uterine tube Top expressed in yolk sac superior frontal gyrus lip thymus cerebellar cortex spermatocyte mirror ganglionic eminence cumulus cell internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding RNA polymerase II core promoter sequence-specific DNA binding metal ion binding nucleic acid binding RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process termination of RNA polymerase II transcription transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of cell population proliferation positive regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of cell migration positive regulation of transcription, DNA-templated positive regulation of protein kinase B signaling negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4150 17188 Ensembl ENSG00000103495 ENSMUSG00000030678 UniProt P56270 P56671 RefSeq (mRNA) NM_001042539 NM_001276275 NM_001276276 NM_002383 NM_010772 NM_001372521 NM_001372522 NM_001372523 RefSeq (protein) NP_001036004 NP_001263204 NP_001263205 NP_002374 n/a Location (UCSC) Chr 16: 29.81 – 29.81 Mb Chr 7: 126.62 – 126.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myc-associated zinc finger protein is a protein that in humans is encoded by the MAZ gene. ^{[5] [6] [7]}

Interactions

MAZ (gene) has been shown to interact with BPTF ^[8] and Deleted in Colorectal Cancer. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000103495 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030678 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pyrc JJ, Moberg KH, Hall DJ (May 1992). "Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter". Biochemistry. 31 (16): 4102–4110. doi:10.1021/bi00131a029. PMID   1567856.
6. Bossone SA, Asselin C, Patel AJ, Marcu KB (September 1992). "MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination". Proc Natl Acad Sci U S A. 89 (16): 7452–7456. Bibcode:1992PNAS...89.7452B. doi: 10.1073/pnas.89.16.7452 . PMC   49728 . PMID   1502157.
7. "Entrez Gene: MAZ MYC-associated zinc finger protein (purine-binding transcription factor)".
8. Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R (March 2000). "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity". Biochemistry. 39 (12): 3206–3215. doi:10.1021/bi992211q. PMC   3667205 . PMID   10727212.
9. Ugai H, Li HO, Komatsu M, Tsutsui H, Song J, Shiga T, Fearon E, Murata T, Yokoyama KK (September 2001). "Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells". Biochem. Biophys. Res. Commun. 286 (5): 1087–1097. doi:10.1006/bbrc.2001.5469. PMID   11527412.

Further reading

• Parks CL, Shenk T (1996). "The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1". J. Biol. Chem. 271 (8): 4417–4430. doi: 10.1074/jbc.271.8.4417 . PMID   8626793.
• Tsutsui H, Sakatsume O, Itakura K, Yokoyama KK (1996). "Members of the MAZ family: a novel cDNA clone for MAZ from human pancreatic islet cells". Biochem. Biophys. Res. Commun. 226 (3): 801–809. doi:10.1006/bbrc.1996.1432. PMID   8831693.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Song J, Murakami H, Tsutsui H, Tang X, Matsumura M, Itakura K, Kanazawa I, Sun K, Yokoyama KK (1998). "Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ)". J. Biol. Chem. 273 (32): 20603–20614. doi: 10.1074/jbc.273.32.20603 . PMID   9685418.
• Song J, Murakami H, Yang ZQ, Koga C, Adati N, Murata T, Geltinger C, Saito-Ohara F, Ikeuchi T, Matsumura M, Itakura K, Kanazawa I, Sun K, Yokoyama KK (1998). "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2". Genomics. 52 (3): 374–377. doi:10.1006/geno.1998.5452. PMID   9790757.
• Tsutsui H, Geltinger C, Murata T, Itakura K, Wada T, Handa H, Yokoyama KK (1999). "The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II". Biochem. Biophys. Res. Commun. 262 (1): 198–205. doi:10.1006/bbrc.1999.1130. PMID   10448092.
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID   10493829.
• Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R (2000). "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity". Biochemistry. 39 (12): 3206–3215. doi:10.1021/bi992211q. PMC   3667205 . PMID   10727212.
• Ugai H, Li HO, Komatsu M, Tsutsui H, Song J, Shiga T, Fearon E, Murata T, Yokoyama KK (2001). "Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells". Biochem. Biophys. Res. Commun. 286 (5): 1087–1097. doi:10.1006/bbrc.2001.5469. PMID   11527412.
• Ray BK, Murphy R, Ray P, Ray A (2003). "SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription". J. Biol. Chem. 277 (48): 46822–46830. doi: 10.1074/jbc.M206299200 . PMID   12270922.
• Bataller L, Wade DF, Graus F, Rosenfeld MR, Dalmau J (2004). "The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction". Ann. Neurol. 53 (1): 123–127. doi:10.1002/ana.10434. PMID   12509857. S2CID   25532793.
• Ray A, Kuroki K, Cook JL, Bal BS, Kenter K, Aust G, Ray BK (2003). "Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis". Arthritis Rheum. 48 (1): 134–145. doi:10.1002/art.10706. PMID   12528113.
• Leroy C, Manen D, Rizzoli R, Lombès M, Silve C (2005). "Functional importance of Myc-associated zinc finger protein for the human parathyroid hormone (PTH)/PTH-related peptide receptor-1 P2 promoter constitutive activity". J. Mol. Endocrinol. 32 (1): 99–113. doi: 10.1677/jme.0.0320099 . PMID   14765995.
• Ray A, Shakya A, Kumar D, Ray BK (2004). "Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression". J. Immunol. 172 (8): 5006–5015. doi: 10.4049/jimmunol.172.8.5006 . PMID   15067082.
• Ray BK, Shakya A, Turk JR, Apte SS, Ray A (2005). "Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process". Circ. Res. 95 (11): 1082–1090. doi: 10.1161/01.RES.0000150046.48115.80 . PMID   15528467.
• Gromak N, West S, Proudfoot NJ (2006). "Pause sites promote transcriptional termination of mammalian RNA polymerase II". Mol. Cell. Biol. 26 (10): 3986–3996. doi:10.1128/MCB.26.10.3986-3996.2006. PMC   1488997 . PMID   16648491.
• Ray A, Shakya A, Kumar D, Benson MD, Ray BK (2006). "Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis". J. Immunol. 177 (4): 2601–2609. doi: 10.4049/jimmunol.177.4.2601 . PMID   16888022.