MC21-B

MC21-B

Names
Preferred IUPAC name 2,2′,3-Tribromo[1,1′-biphenyl]-4,4′-dicarboxylic acid
Other names 2,2′,3-Tribromobiphenyl-4,4′-dicarboxylic acid
Identifiers
3D model (JSmol)	Interactive image
PubChem CID	44181740
CompTox Dashboard (EPA)	DTXSID301028290
InChI InChI=1S/C14H7Br3O4/c15-10-5-6(13(18)19)1-2-7(10)8-3-4-9(14(20)21)12(17)11(8)16/h1-5H,(H,18,19)(H,20,21) Key: BTFCVLPFWWMQRI-UHFFFAOYSA-N
SMILES OC(=O)c1cc(Br)c(cc1)c2c(Br)c(Br)c(cc2)C(=O)O
Properties
Chemical formula	C14H7Br3O4
Molar mass	478.918 g·mol−1
Appearance	White powder
Solubility in water	Sol. MeOH, CHCl3 insol. H2O, hexane
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

MC21-B is an antibiotic isolated from the O-BC30T strain of a marine bacterium, Pseudoalteromonas phenolica . ^[1] MC21-B is cytotoxic to human leukaemia cells and human normal dermal fibroblasts. ^[2]

See also

• MC21-A

References

1. Isnansetyo, A.; Kamei, Y. (2009). "Anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of MC21-B, an antibacterial compound produced by the marine bacterium Pseudoalteromonas phenolica O-BC30T". International Journal of Antimicrobial Agents. 34 (2): 131–135. doi:10.1016/j.ijantimicag.2009.02.009. PMID   19329285.
2. Rahman, H.; Austin, B.; Mitchell, W. J.; Morris, P. C.; Jamieson, D. J.; Adams, D. R.; Spragg, A. M.; Schweizer, M. (2010). "Novel Anti-Infective Compounds from Marine Bacteria". Marine Drugs. 8 (3): 498–518. doi: 10.3390/md8030498 . PMC   2857357 . PMID   20411112.