In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.
Pseudoalteromonas is a genus of marine bacteria. In 1995, Gauthier et al proposed Pseudoalteromonas as a new genus to be split from Alteromonas. The Pseudoalteromonas species that were described before 1995 were originally part of the genus Alteromonas, and were reassigned to Pseudoalteromonas based on their rRNA-DNA analysis.
Colitose is a mannose-derived 3,6-dideoxysugar produced by certain bacteria. It is a constituent of the lipopolysaccharide.
Alteromonas is a genus of Pseudomonadota found in sea water, either in the open ocean or in the coast. It is Gram-negative. Its cells are curved rods with a single polar flagellum.
Salinosporamide A (Marizomib) is a potent proteasome inhibitor being studied as a potential anticancer agent. It entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. This marine natural product is produced by the obligate marine bacteria Salinispora tropica and Salinispora arenicola, which are found in ocean sediment. Salinosporamide A belongs to a family of compounds, known collectively as salinosporamides, which possess a densely functionalized γ-lactam-β-lactone bicyclic core.
Corticovirus is a genus of viruses in the family Corticoviridae. Corticoviruses are bacteriophages; that is, their natural hosts are bacteria. The genus contains two species. The name is derived from Latin cortex, corticis. However, prophages closely related to PM2 are abundant in the genomes of aquatic bacteria, suggesting that the ecological importance of corticoviruses might be underestimated. Bacteriophage PM2 was first described in 1968 after isolation from seawater sampled from the coast of Chile.
Faecalibacterium is a genus of bacteria. Its sole known species, Faecalibacterium prausnitzii is gram-positive, mesophilic, rod-shaped, anaerobic and is one of the most abundant and important commensal bacteria of the human gut microbiota. It is non-spore forming and non-motile. These bacteria produce butyrate and other short-chain fatty acids through the fermentation of dietary fiber.
Lambda-carrageenase is an enzyme which breaks down a polysaccharide found in red seaweeds, lambda-carrageenan. This enzyme has only been found in marine bacteria.
Algicola is a genus in the phylum Pseudomonadota (Bacteria).
Pseudoalteromonas phenolica is a marine bacterium species in the genus Pseudoalteromonas.
Pseudoalteromonas aurantia is an antibacterial-producing marine bacterium commonly found in Mediterranean waters. In 1979, Gauthier and Breittmayer first named it Alteromonas aurantia to include it in the genus Alteromonas that was described seven years earlier, in 1972 by Baumann et al. In 1995, Gauthier et al renamed Alteromonas aurantia to Pseudoalteromonas aurantia to include it in their proposed new genus, Pseudoalteromonas, which they recommended splitting from Alteromonas.
Pseudoalteromonas distincta is a marine bacterium.
Algicola sagamiensis is a marine bacterium isolated from sea water in Sagami Bay. It was originally named Pseudoalteromonas sagamiensis but was reclassified in 2007 into the genus Algicola.
Pseudoalteromonas lipolytica is a marine bacterium which was isolated from the Yangtze River.
Pseudoalteromonas marina is a marine bacterium isolated from tidal sediment near Chungnam.
Kappa-carrageenase is an enzyme with systematic name kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining). This enzyme catalyses the following chemical reaction
Beta porphyranase is an enzyme responsible for the degradation of porphyran, which composes the cell wall of red algae. So far only five β-porphyranases have been identified: PorA and PorB are found in the marine bacteria Zobellia galactinovirans. A wild-type porphyranase activity has been found in Pseudoalteromonas atlantica. BpGH16B and BpGH86A have been found in the human gut bactrium, Bacteroides plebeius, of Japanese individuals.
MC21-A (bromophene) is an bactericidal antibiotic isolated from the O-BC30 strain of a new marine bacterium, Pseudoalteromonas phenolica.
Tambjamines are a group of natural products that are structurally related to the prodiginines. They are enamine derivatives of 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC).
Pentabromopseudilin, the first reported marine microbial antibiotic, is a bioactive natural product that contains a highly halogenated 2-arrylpyrrole moiety. Pentabromopseudilin (PBP) is a unique hybrid bromophenol-bromopyrrole compound that is made up of over 70% bromine atoms, contributing to its potent bioactivity. PBP was first isolated from Pseudomonas bromoutilis, and has since been found to be produced by other marine microbes, including Alteromonas luteoviolaceus, Chromobacteria, and Pseudoalteromonas spp.
