MCF2L

MCF2L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KZ7, 1KZG, 1LB1, 1RJ2
Identifiers
Aliases	MCF2L , ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like
External IDs	OMIM: 609499; MGI: 103263; HomoloGene: 11804; GeneCards: MCF2L; OMA:MCF2L - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q34 Start 112,894,378 bp [1] End 113,099,742 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A1.1 Start 12,873,806 bp [2] End 13,020,905 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe paraflocculus of cerebellum pituitary gland apex of heart anterior pituitary C1 segment Brodmann area 9 prefrontal cortex primary visual cortex Top expressed in olfactory epithelium neural layer of retina cerebellar cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell pituitary gland lobe of cerebellum cerebellar vermis islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol binding lipid binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm extrinsic component of cytoplasmic side of plasma membrane cytosol plasma membrane membrane endomembrane system extracellular space Biological process positive regulation of Rho protein signal transduction regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction positive regulation of apoptotic process G protein-coupled receptor signaling pathway regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23263 17207 Ensembl ENSG00000126217 ENSMUSG00000031442 UniProt O15068 Q64096 RefSeq (mRNA) NM_001112732 NM_024979 NM_001320815 NM_001320816 NM_001320817 NM_001366644 NM_001366645 NM_001366646 NM_001159485 NM_001159486 NM_178076 RefSeq (protein) NP_001106203 NP_001307744 NP_001307745 NP_001307746 NP_079255 NP_001353573 NP_001353574 NP_001353575 n/a Location (UCSC) Chr 13: 112.89 – 113.1 Mb Chr 8: 12.87 – 13.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000126217 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031442 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID   9205841.
6. "Entrez Gene: MCF2L MCF.2 cell line derived transforming sequence-like".

Further reading

• Horii Y, Beeler JF, Sakaguchi K, Tachibana M, Miki T (Oct 1994). "A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways". The EMBO Journal. 13 (20): 4776–86. doi:10.1002/j.1460-2075.1994.tb06803.x. PMC   395416 . PMID   7957046.
• Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J (Mar 2002). "A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange". The EMBO Journal. 21 (6): 1315–26. doi:10.1093/emboj/21.6.1315. PMC   125919 . PMID   11889037.
• Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID   12006984. S2CID   13161854.
• Yamauchi J, Hirasawa A, Miyamoto Y, Kokubu H, Nishii H, Okamoto M, Sugawara Y, Tsujimoto G, Itoh H (Aug 2002). "Role of Dbl's big sister in the anti-mitogenic pathway from alpha1B-adrenergic receptor to c-Jun N-terminal kinase". Biochemical and Biophysical Research Communications. 296 (1): 85–92. doi:10.1016/S0006-291X(02)00839-2. PMID   12147231.
• Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (Dec 2002). "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry. 277 (49): 47810–7. doi: 10.1074/jbc.M203816200 . PMID   12376551.
• Cheng L, Mahon GM, Kostenko EV, Whitehead IP (Mar 2004). "Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1". The Journal of Biological Chemistry. 279 (13): 12786–93. doi: 10.1074/jbc.M313099200 . PMID   14701795.
• Ueda S, Kataoka T, Satoh T (Aug 2004). "Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites" (PDF). Cellular Signalling. 16 (8): 899–906. doi:10.1016/j.cellsig.2004.01.007. hdl:20.500.14094/D1002967. PMID   15157669. Archived from the original (PDF) on 2020-07-21. Retrieved 2020-07-21.
• Kostenko EV, Mahon GM, Cheng L, Whitehead IP (Jan 2005). "The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs". The Journal of Biological Chemistry. 280 (4): 2807–17. doi: 10.1074/jbc.M411139200 . PMID   15531584.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ieguchi K, Ueda S, Kataoka T, Satoh T (Aug 2007). "Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1". The Journal of Biological Chemistry. 282 (32): 23296–305. doi: 10.1074/jbc.M700950200 . hdl: 20.500.14094/D1004143 . PMID   17562712.