MCM3AP

MCM3AP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DHX
Identifiers
Aliases	MCM3AP , GANP, MAP80, SAC3, minichromosome maintenance complex component 3 associated protein, PNRIID
External IDs	OMIM: 603294 MGI: 1930089 HomoloGene: 2902 GeneCards: MCM3AP
Gene location (Human)
Chr.	Chromosome 21 (human)
End	46,286,297 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,351,691 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; right uterine tube; ; gastrocnemius muscle; ; gastric mucosa; ; right lobe of thyroid gland; ; cerebellar hemisphere; ; left lobe of thyroid gland; ; left uterine tube; ; canal of the cervix; ; anterior pituitary;
	Top expressed in
	saccule; ; otic placode; ; secondary oocyte; ; renal corpuscle; ; maxillary prominence; ; medullary collecting duct; ; superior cervical ganglion; ; external carotid artery; ; thymus; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; DNA binding ; acyltransferase activity ; nucleic acid binding ; chromatin binding ; histone acetyltransferase activity ; protein binding ; H3 histone acetyltransferase activity ; histone binding ;
Cellular component	cytosol ; nuclear pore ; nuclear membrane ; nuclear envelope ; nucleus ; nucleoplasm ; cytoplasm ; transcription export complex 2 ; nuclear pore nuclear basket ; chromosome ;
Biological process	protein transport ; mRNA transport ; protein import into nucleus ; immune system process ; transport ; mRNA export from nucleus ; poly(A)+ mRNA export from nucleus ; somatic hypermutation of immunoglobulin genes ; histone acetylation ; nucleosome organization ; histone H3 acetylation ;
	Sources:Amigo / QuickGO
Orthologs
	8888
	54387
	ENSG00000160294
	ENSMUSG00000001150
	O60318
	Q9WUU9
	NM_003906
	NM_019434
	NP_003897
	NP_062307
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 15, 2023

80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.^[5]^[6]

Function

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.^[6]

Interactions

MCM3AP has been shown to interact with:

MCM3 ^[5]^[7]^[8] and
TRIB3.^[9]

Related Research Articles

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Bik Kwoon Yeung Tye is a Chinese-American molecular geneticist and structural biologist. Tye's pioneering work on eukaryotic DNA replication led to the discovery of the minichromosome maintenance (MCM) genes in 1984, which encode the catalytic core of the eukaryotic replisome. Tye also determined the first high-resolution structures of both the MCM complex and the Origin Recognition Complex (ORC) in 2015 and 2018. Tye is currently a Professor Emeritus (2015) at Cornell University and a visiting professor at the Hong Kong University of Science & Technology. She is married to Henry Sze-Hoi Tye and is the mother of Kay Tye and Lynne Tye.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160294 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001150 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Takei Y, Tsujimoto G (September 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. doi: 10.1074/jbc.273.35.22177 . PMID 9712829.
1 2 "Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein".
↑ Takei Y, Assenberg M, Tsujimoto G, Laskey R (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. 277 (45): 43121–5. doi: 10.1074/jbc.C200442200 . PMID 12226073.
↑ Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. doi:10.1182/blood.V95.7.2321. PMID 10733502.
↑ Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Germinal-center associated nuclear protein (MCM3AP)

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160294 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001150 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9712829-5] 1 2 Takei Y, Tsujimoto G (September 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. doi: 10.1074/jbc.273.35.22177 . PMID 9712829.

[entrez-6] 1 2 "Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein".

[pmid12226073-7] Takei Y, Assenberg M, Tsujimoto G, Laskey R (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. 277 (45): 43121–5. doi: 10.1074/jbc.C200442200 . PMID 12226073.

[pmid10733502-8] Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. doi:10.1182/blood.V95.7.2321. PMID 10733502.

[pmid18276110-9] Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

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