MDGA2

MAM domain containing glycosylphosphatidylinositol anchor 2
Identifiers
Symbol	MDGA2
Alt. symbols	MAMDC1
NCBI gene	161357
HGNC	19835
OMIM	611128
RefSeq	NM_182830
Other data
Locus	Chr. 14 q21.2

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1. ^[1] MDGA2 is located on chromosome 14.

The gene has a homologue in rat and mouse, Mdga2, ^[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex. ^[3]

There are several variants in the human gene, ^[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism. ^[5] However, a more recent study has failed to replicate that finding. ^[6]

References

1. "MDGA2 Gene — GeneCards". Weizmann Institute of Science. 2008-09-08.
2. "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. Retrieved 2008-11-14.
3. Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD (February 2004). "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neuroscience . 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID   15019943. S2CID   25186151.
4. "SNP linked to Gene MDGA2". NCBI.
5. van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D (September 2008). "18762592" . Archives of General Psychiatry . 65 (9): 1062–1071. doi:10.1001/archpsyc.65.9.1062. PMID   18762592.
6. Hettema, John M.; Oord, Edwin J.C.G. van den; An, Seon-Sook; Kendler, Kenneth S.; Chen, Xiangning (2009). "Follow-up association study of novel neuroticism gene MAMDC1". Psychiatric Genetics. 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMC   2844892 . PMID   19440164.