MEAF6

MEAF6
Identifiers
Aliases	MEAF6 , C1orf149, CENP-28, EAF6, NY-SAR-91, MYST/Esa1 associated factor 6
External IDs	OMIM: 611001; MGI: 1917338; HomoloGene: 11240; GeneCards: MEAF6; OMA:MEAF6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.3 Start 37,489,993 bp [1] End 37,514,766 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.2 Start 124,978,927 bp [2] End 125,007,031 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ganglionic eminence Achilles tendon anterior pituitary pons secondary oocyte islet of Langerhans seminal vesicula prefrontal cortex bronchial epithelial cell Top expressed in superior cervical ganglion neural layer of retina genital tubercle tail of embryo superior frontal gyrus ventricular zone hand neural tube zygote dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding histone acetyltransferase activity (H3-K23 specific) Cellular component NuA4 histone acetyltransferase complex MOZ/MORF histone acetyltransferase complex histone acetyltransferase complex nucleus nucleolus chromosome kinetochore chromosome, centromeric region nucleoplasm NuA3a histone acetyltransferase complex NuA3b histone acetyltransferase complex Biological process histone H4-K12 acetylation regulation of transcription, DNA-templated histone H4-K5 acetylation histone acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone H3-K14 acetylation histone H2A acetylation transcription, DNA-templated regulation of signal transduction by p53 class mediator chromatin organization histone H3-K23 acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64769 70088 Ensembl ENSG00000163875 ENSMUSG00000028863 UniProt Q9HAF1 Q2VPQ9 RefSeq (mRNA) NM_001270875 NM_001270876 NM_022756 NM_001290701 NM_027310 NM_001374123 RefSeq (protein) NP_001257804 NP_001257805 NP_073593 NP_001277630 NP_081586 NP_001361052 Location (UCSC) Chr 1: 37.49 – 37.51 Mb Chr 4: 124.98 – 125.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chromatin modification-related protein MEAF6 is a protein that in humans is encoded by the MEAF6 gene. ^{[5] [6] [7] [8] [9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000163875 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028863 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
6. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
7. Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J Biol Chem. 278 (44): 42733–6. doi: 10.1074/jbc.C300389200 . PMID   12963728.
8. Doyon Y, Selleck W, Lane WS, Tan S, Cote J (Feb 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Mol Cell Biol. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC   350560 . PMID   14966270.
9. Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J (Jan 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol Cell. 21 (1): 51–64. doi: 10.1016/j.molcel.2005.12.007 . PMID   16387653.
10. "Entrez Gene: C1orf149 chromosome 1 open reading frame 149".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lee SY, Obata Y, Yoshida M, et al. (2003). "Immunomic analysis of human sarcoma". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2651–6. Bibcode:2003PNAS..100.2651L. doi: 10.1073/pnas.0437972100 . PMC   151395 . PMID   12601173.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi: 10.1074/jbc.M500001200 . PMID   15647280.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.