MED11

MED11
Identifiers
Aliases	MED11 , HSPC296, mediator complex subunit 11
External IDs	OMIM: 612383 MGI: 1913422 HomoloGene: 32630 GeneCards: MED11
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,733,608 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,344,553 bp
RNA expression pattern
	Top expressed in
	Right adrenal gland; ; Left adrenal gland; ; deltoid muscle; ; body of stomach; ; gastrocnemius muscle; ; spleen; ; right lobe of liver; ; kidney; ; tibialis anterior muscle; ; blood;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; yolk sac; ; molar; ; paraventricular nucleus of hypothalamus; ; medial vestibular nucleus; ; maxillary prominence; ; globus pallidus; ; endocardial cushion; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coregulator activity ; protein binding ; ubiquitin protein ligase activity ;
Cellular component	mediator complex ; nucleus ; ubiquitin ligase complex ;
Biological process	regulation of transcription by RNA polymerase II ; regulation of transcription, DNA-templated ; protein ubiquitination ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	400569
	66172
	ENSG00000161920
	ENSMUSG00000018923
	Q9P086
	Q9D8C6
	NM_001305000 ; NM_001001683
	NM_025397
	NP_001001683 ; NP_001291929
	NP_079673
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.^[5]

Function

Med11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.^[6]

Related Research Articles

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene. It represents subunit Med30 of the Mediator complex and is metazoan-specific, having no homologues in yeasts.

Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene.

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.

Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.

Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene. It forms part of the Mediator complex.

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.

Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene.

Mediator complex subunit 9 (Med9) is a protein that in humans is encoded by the MED9 gene.

Mediator complex subunit 10 (Med10) is a protein that in humans is encoded by the MED10 gene.

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.

Mediator complex subunit 19 (Med19) is a protein that in humans is encoded by the MED19 gene.

Mediator complex subunit 12 like (Med12L) is a protein that in humans is encoded by the MED12L gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000161920 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018923 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Mediator complex subunit 11".
↑ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. American Society for Biochemistry & Molecular Biology (ASBMB). 278 (17): 15123–7. doi: 10.1074/jbc.c300054200 . PMID 12584197.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000161920 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018923 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mediator complex subunit 11".

[Sato_Tomomori-Sato_Banks_Sorokina_pp._15123–15127-6] Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. American Society for Biochemistry & Molecular Biology (ASBMB). 278 (17): 15123–7. doi: 10.1074/jbc.c300054200 . PMID 12584197.

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MED11

Contents

Function

See also

Related Research Articles

References