MED18

MED18
Identifiers
Aliases	MED18 , p28b, mediator complex subunit 18, SRB5
External IDs	OMIM: 612384 MGI: 1914469 HomoloGene: 9756 GeneCards: MED18
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,335,965 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,191,232 bp
RNA expression pattern
	Top expressed in
	blood; ; stomach; ; thymus; ; colon; ; islet of Langerhans; ; lymph node; ; muscle of leg; ; rectum;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001104 transcription coregulator activity ; GO:0001948 protein binding ; GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity ;
Cellular component	core mediator complex ; mediator complex ; nucleus ; ubiquitin ligase complex ;
Biological process	regulation of transcription by RNA polymerase II ; termination of RNA polymerase II transcription ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; protein ubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	54797
	67219
	ENSG00000130772 ; ENSG00000284944
	ENSMUSG00000066042
	Q9BUE0
	Q9CZ82
	NM_001127350 ; NM_017638
	NM_026039
	NP_001120822 ; NP_060108
	NP_080315
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2022

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.^[5]

Function

Med18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.^[6]

Related Research Articles

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene. It represents subunit Med30 of the Mediator complex and is metazoan-specific, having no homologues in yeasts.

Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene.

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.

Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.

Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene. It forms part of the Mediator complex.

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.

V-type proton ATPase subunit C 2 is an enzyme that in humans is encoded by the ATP6V1C2 gene.

Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene.

Integrator complex subunit 5 is a protein that in humans is encoded by the INTS5 gene.

Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.

Mediator complex subunit 9 (Med9) is a protein that in humans is encoded by the MED9 gene.

Mediator complex subunit 10 (Med10) is a protein that in humans is encoded by the MED10 gene.

Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.

Mediator complex subunit 19 (Med19) is a protein that in humans is encoded by the MED19 gene.

Mediator complex subunit 12 like (Med12L) is a protein that in humans is encoded by the MED12L gene.

References

1 2 3 ENSG00000284944 GRCh38: Ensembl release 89: ENSG00000130772, ENSG00000284944 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066042 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Mediator complex subunit 18".
↑ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. American Society for Biochemistry & Molecular Biology (ASBMB). 278 (17): 15123–7. doi: 10.1074/jbc.c300054200 . PMID 12584197.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000284944 GRCh38: Ensembl release 89: ENSG00000130772, ENSG00000284944 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066042 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mediator complex subunit 18".

[Sato_Tomomori-Sato_Banks_Sorokina_pp._15123–15127-6] Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. American Society for Biochemistry & Molecular Biology (ASBMB). 278 (17): 15123–7. doi: 10.1074/jbc.c300054200 . PMID 12584197.

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MED18

Contents

Function

See also

Related Research Articles

References