METTL2B

METTL2B
Identifiers
Aliases	METTL2B , METL, METTL2, METTL2A, PSENIP1, methyltransferase like 2B, methyltransferase 2B, methylcytidine
External IDs	OMIM: 607846; MGI: 1289171; HomoloGene: 130696; GeneCards: METTL2B; OMA:METTL2B - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q32.1 Start 128,476,729 bp [1] End 128,506,602 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 E1|11 68.61 cM Start 105,017,251 bp [2] End 105,031,220 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon cerebellar vermis islet of Langerhans quadriceps femoris muscle skeletal muscle tissue gonad endometrium tonsil stromal cell of endometrium muscle of thigh Top expressed in otic vesicle hand spermatocyte tail of embryo epiblast Rostral migratory stream abdominal wall primitive streak embryo ventricular zone More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55798 52686 Ensembl ENSG00000165055 ENSMUSG00000020691 UniProt Q6P1Q9 Q8BMK1 RefSeq (mRNA) NM_018396 NM_172567 RefSeq (protein) NP_060866 NP_766155 Location (UCSC) Chr 7: 128.48 – 128.51 Mb Chr 11: 105.02 – 105.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Methyltransferase-like protein 2B is an enzyme that in humans is encoded by the METTL2B gene. ^{[5] [6]}

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000165055 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020691 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang SX, Guo Y, Boulianne GL (Dec 2001). "Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins". Gene. 280 (1–2): 135–44. doi:10.1016/S0378-1119(01)00770-3. PMID   11738826.
6. "Entrez Gene: METTL2B methyltransferase like 2B".

Further reading

• Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC   2610434 . PMID   16625196.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.