MFAP5

MFAP5
Identifiers
Aliases	MFAP5 , MAGP-2, MAGP2, MFAP-5, MP25, AAT9, microfibrillar associated protein 5, microfibril associated protein 5
External IDs	OMIM: 601103; MGI: 1354387; HomoloGene: 2599; GeneCards: MFAP5; OMA:MFAP5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.31 Start 8,637,346 bp [1] End 8,662,888 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F1 Start 122,482,804 bp [2] End 122,506,249 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint skin of hip tibial nerve smooth muscle tissue pericardium placenta right coronary artery vena cava urethra decidua Top expressed in decidua gastrula ascending aorta sciatic nerve aortic valve cervix ankle esophagus intercostal muscle extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent Cellular component extracellular region microfibril extracellular matrix collagen-containing extracellular matrix Biological process definitive hemopoiesis extracellular matrix organization supramolecular fiber organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8076 50530 Ensembl ENSG00000197614 ENSMUSG00000030116 UniProt Q13361 Q9QZJ6 RefSeq (mRNA) NM_001297709 NM_001297710 NM_001297711 NM_001297712 NM_003480 NM_015776 NM_001347434 RefSeq (protein) NP_001284638 NP_001284639 NP_001284640 NP_001284641 NP_003471 NP_001334363 NP_056591 Location (UCSC) Chr 12: 8.64 – 8.66 Mb Chr 6: 122.48 – 122.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene. ^{[5] [6] [7]}

This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000197614 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030116 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hatzinikolas G, Gibson MA (Dec 1998). "The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region". J Biol Chem. 273 (45): 29309–14. doi: 10.1074/jbc.273.45.29309 . PMID   9792630.
6. Gibson MA, Hatzinikolas G, Kumaratilake JS, Sandberg LB, Nicholl JK, Sutherland GR, Cleary EG (Feb 1996). "Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)". J Biol Chem. 271 (2): 1096–103. doi: 10.1074/jbc.271.2.1096 . PMID   8557636.
7. "Entrez Gene: MFAP5 microfibrillar associated protein 5".

Further reading

• Miyamoto A, Lau R, Hein PW, et al. (2006). "Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation". J. Biol. Chem. 281 (15): 10089–97. doi: 10.1074/jbc.M600298200 . PMID   16492672.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID   12878157.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Penner AS, Rock MJ, Kielty CM, Shipley JM (2002). "Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly". J. Biol. Chem. 277 (38): 35044–9. doi: 10.1074/jbc.M206363200 . PMID   12122015.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.