MFAP5

MFAP5
Identifiers
Aliases	MFAP5 , MAGP-2, MAGP2, MFAP-5, MP25, AAT9, microfibrillar associated protein 5, microfibril associated protein 5
External IDs	OMIM: 601103 MGI: 1354387 HomoloGene: 2599 GeneCards: MFAP5
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,662,888 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,506,249 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; tibial nerve; ; smooth muscle tissue; ; pericardium; ; placenta; ; right coronary artery; ; vena cava; ; urethra; ; subcutaneous adipose tissue; ; saphenous vein;
	Top expressed in
	ascending aorta; ; sciatic nerve; ; aortic valve; ; cervix; ; ankle; ; esophagus; ; intercostal muscle; ; extraocular muscle; ; lip; ; optic nerve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent ;
Cellular component	extracellular region ; microfibril ; extracellular matrix ; collagen-containing extracellular matrix ;
Biological process	definitive hemopoiesis ; extracellular matrix organization ; supramolecular fiber organization ;
	Sources:Amigo / QuickGO
Orthologs
	8076
	50530
	ENSG00000197614
	ENSMUSG00000030116
	Q13361
	Q9QZJ6
	NM_001297709 ; NM_001297710 ; NM_001297711 ; NM_001297712 ; NM_003480
	NM_015776 ; NM_001347434
	NP_001284638 ; NP_001284639 ; NP_001284640 ; NP_001284641 ; NP_003471
	NP_001334363 ; NP_056591
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 16, 2023

Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene.^[5]^[6]^[7]

This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.^[7]

Related Research Articles

Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene, located on chromosome 15. It is a large, extracellular matrix glycoprotein that serves as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations altering the protein can result in a variety of phenotypic effects differing widely in their severity, including fetal death, developmental problems, Marfan syndrome or in some cases Weill-Marchesani syndrome.

Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.

Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.

Microfibrillar-associated protein 2 is a protein that in humans is encoded by the MFAP2 gene.

Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.

Procollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene.

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.

Elastin microfibril interfacer 1 (EMILIN-1) is a protein that in humans is encoded by the EMILIN1 gene. It is the best characterized member of the EMILIN family of extracellular matrix glycoproteins.

Sulfiredoxin-1 is a protein that in humans is encoded by the SRXN1 gene.

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.

ETS homologous factor is a protein that in humans is encoded by the EHF gene. This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Rh family, B glycoprotein, also known as RHBG, is an ammonia transporter protein which in humans is encoded by the RHBG gene.

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.

39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.

Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) is a gene located on human chromosome 12p11. It encodes a protein of 377 amino acid residues. ERGIC2 protein is also known as PTX1, CDA14 or Erv41.

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.

Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197614 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030116 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hatzinikolas G, Gibson MA (Dec 1998). "The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region". J Biol Chem. 273 (45): 29309–14. doi: 10.1074/jbc.273.45.29309 . PMID 9792630.
↑ Gibson MA, Hatzinikolas G, Kumaratilake JS, Sandberg LB, Nicholl JK, Sutherland GR, Cleary EG (Feb 1996). "Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)". J Biol Chem. 271 (2): 1096–103. doi: 10.1074/jbc.271.2.1096 . PMID 8557636.
1 2 "Entrez Gene: MFAP5 microfibrillar associated protein 5".

Miyamoto A, Lau R, Hein PW, et al. (2006). "Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation". J. Biol. Chem. 281 (15): 10089–97. doi: 10.1074/jbc.M600298200 . PMID 16492672.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Penner AS, Rock MJ, Kielty CM, Shipley JM (2002). "Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly". J. Biol. Chem. 277 (38): 35044–9. doi: 10.1074/jbc.M206363200 . PMID 12122015.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197614 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030116 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9792630-5] Hatzinikolas G, Gibson MA (Dec 1998). "The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region". J Biol Chem. 273 (45): 29309–14. doi: 10.1074/jbc.273.45.29309 . PMID 9792630.

[pmid8557636-6] Gibson MA, Hatzinikolas G, Kumaratilake JS, Sandberg LB, Nicholl JK, Sutherland GR, Cleary EG (Feb 1996). "Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)". J Biol Chem. 271 (2): 1096–103. doi: 10.1074/jbc.271.2.1096 . PMID 8557636.

[entrez-7] 1 2 "Entrez Gene: MFAP5 microfibrillar associated protein 5".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

MFAP5

Related Research Articles

References

Further reading