MFN1

MFN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T3J
Identifiers
Aliases	MFN1 , hfzo1, hfzo2, mitofusin 1
External IDs	OMIM: 608506; MGI: 1914664; HomoloGene: 11481; GeneCards: MFN1; OMA:MFN1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q26.33 Start 179,347,709 bp [1] End 179,394,936 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 A3|3 15.75 cM Start 32,583,614 bp [2] End 32,633,388 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon body of pancreas gastric mucosa epithelium of colon right hemisphere of cerebellum right uterine tube right auricle of heart skin of leg canal of the cervix Top expressed in myocardium of ventricle digastric muscle right ventricle cardiac muscle tissue of left ventricle extraocular muscle soleus muscle extensor digitorum longus muscle muscle of thigh thoracic diaphragm sternocleidomastoid muscle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding hydrolase activity GTPase activity Cellular component cytoplasm mitochondrial outer membrane mitochondrion membrane integral component of mitochondrial outer membrane outer mitochondrial membrane protein complex integral component of membrane intrinsic component of mitochondrial outer membrane Biological process mitochondrial fusion macroautophagy GTP metabolic process mitochondrion localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55669 67414 Ensembl ENSG00000171109 ENSMUSG00000027668 UniProt Q8IWA4 Q811U4 RefSeq (mRNA) NM_017927 NM_033540 NM_024200 RefSeq (protein) NP_284941 NP_077162 Location (UCSC) Chr 3: 179.35 – 179.39 Mb Chr 3: 32.58 – 32.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. ^{[5] [6] [7]}

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171109 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027668 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID   8358434. S2CID   20528590.
6. Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci. 114 (Pt 5): 867–74. doi: 10.1242/jcs.114.5.867 . PMID   11181170.
7. "Entrez Gene: MFN1 mitofusin 1".

Further reading

• Pawlikowska P, Orzechowski A (2007). "[Role of transmembrane GTPases in mitochondrial morphology and activity]". Postepy Biochem. 53 (1): 53–9. PMID   17718388.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Hales KG, Fuller MT (1997). "Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase". Cell. 90 (1): 121–9. doi: 10.1016/S0092-8674(00)80319-0 . PMID   9230308. S2CID   15162087.
• Chung JG, Yeh KT, Wu SL, et al. (2002). "Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display". Cancer Res. 61 (24): 8873–9. PMID   11751411.
• Rojo M, Legros F, Chateau D, Lombès A (2003). "Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo". J. Cell Sci. 115 (Pt 8): 1663–74. doi:10.1242/jcs.115.8.1663. PMID   11950885.
• Legros F, Lombès A, Frachon P, Rojo M (2003). "Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins". Mol. Biol. Cell. 13 (12): 4343–54. doi:10.1091/mbc.E02-06-0330. PMC   138638 . PMID   12475957.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Santel A, Frank S, Gaume B, et al. (2004). "Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells". J. Cell Sci. 116 (Pt 13): 2763–74. doi:10.1242/jcs.00479. PMID   12759376. S2CID   6661619.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004). "OPA1 requires mitofusin 1 to promote mitochondrial fusion". Proc. Natl. Acad. Sci. U.S.A. 101 (45): 15927–32. Bibcode:2004PNAS..10115927C. doi: 10.1073/pnas.0407043101 . PMC   528769 . PMID   15509649.
• Cartoni R, Léger B, Hock MB, et al. (2005). "Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise". J. Physiol. 567 (Pt 1): 349–58. doi:10.1113/jphysiol.2005.092031. PMC   1474174 . PMID   15961417.