MFNG

MFNG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2J0A, 2J0B
Identifiers
Aliases	MFNG , MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
External IDs	OMIM: 602577 MGI: 1095404 HomoloGene: 1803 GeneCards: MFNG
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,486,393 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,657,675 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; lymph node; ; spleen; ; appendix; ; bone marrow cells; ; right lung; ; upper lobe of left lung; ; thymus; ; gallbladder;
	Top expressed in
	medial ganglionic eminence; ; subcutaneous adipose tissue; ; white adipose tissue; ; thymus; ; spleen; ; blood; ; Jacobson's organ; ; external carotid artery; ; brown adipose tissue; ; saccule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity ; metal ion binding ; glycosyltransferase activity ; acetylglucosaminyltransferase activity ;
Cellular component	integral component of membrane ; integral component of Golgi membrane ; Golgi membrane ; Golgi apparatus ; membrane ; extracellular space ;
Biological process	pattern specification process ; multicellular organism development ; positive regulation of protein binding ; marginal zone B cell differentiation ; positive regulation of Notch signaling pathway ; regulation of Notch signaling pathway ; protein O-linked fucosylation ; blastocyst formation ;
	Sources:Amigo / QuickGO
Orthologs
	4242
	17305
	ENSG00000100060
	ENSMUSG00000018169
	O00587
	O09008
	NM_001166343 ; NM_002405
	NM_008595
	NP_001159815 ; NP_002396
	NP_032621
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene,^[5]^[6]^[7] a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG).^[8]^[9]

They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.^[7]

Related Research Articles

Fringe genes are important in the workings of the notch signaling pathway.

Neuromedin-U receptor 1 is a protein that in humans is encoded by the NMUR1 gene.

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.

Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene.

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene.

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.

DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene.

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene.

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, (Lunatic Fringe), is a protein encoded in humans by the LFNG gene.

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.

Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase is an enzyme that in humans is encoded by the ALG12 gene.

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.

GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene.

39S ribosomal protein L40, mitochondrial is a protein that in humans is encoded by the MRPL40 gene.

Chondroitin sulfate synthase 2 is an enzyme that in humans is encoded by the CHPF gene.

GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.

Beta-1,3-N-acetylglucosaminyltransferase radical fringe, also known as radical fringe is a protein that in humans is encoded by the RFNG gene. Radical fringe is a signaling enzyme involved in the arrangement of the embryonic limb buds. It is a member of the fringe gene family, which also includes manic fringe and lunatic fringe. It is important for the dorsoventrally patterning of the limb and has been implicated in the formation of the apical ectodermal ridge (AER). The AER is essential for the distal patterning of the limb. Experiments executed in chicken models show Radical fringe is expressed in both the dorsal ectoderm and the AER. This provides evidence that the AER forms from cells already expressing radical fringe, though further evidence is needed to confirm. Grafting experiments have shown that formation of the AER comes from signals in the limb bud mesoderm. However, radical fringe acts as a permissive signal to create a boundary for the AER to form. The knockout experiments done in chicken models suggest Radical fringe plays an integral role in wing development.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100060 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018169 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW (Feb 1999). "Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12". Genomics. 54 (3): 576–7. doi:10.1006/geno.1998.5559. PMID 9878264.
↑ Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF (Jul 1997). "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway". Development. 124 (11): 2245–54. doi:10.1242/dev.124.11.2245. PMID 9187150.
1 2 "Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase".
↑ "Troublesome gene names get the boot", 6 November 2006, Michael Hopkin, nature.com
↑ "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com

Cohen B, Bashirullah A, Dagnino L, et al. (1997). "Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila". Nat. Genet. 16 (3): 283–8. doi:10.1038/ng0797-283. PMID 9207795. S2CID 28033622.
Moran JL, Johnston SH, Rauskolb C, et al. (1999). "Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes". Mamm. Genome. 10 (6): 535–41. doi:10.1007/s003359901039. PMID 10341080. S2CID 27214129.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Van Tine BA, Knops J, Shaw GM, May WA (2000). "Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH)". Cytogenet. Cell Genet. 87 (1–2): 132–3. doi:10.1159/000015379. PMID 10640833. S2CID 24323351.
Moloney DJ, Panin VM, Johnston SH, et al. (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature. 406 (6794): 369–75. Bibcode:2000Natur.406..369M. doi:10.1038/35019000. PMID 10935626. S2CID 4382611.
Shimizu K, Chiba S, Saito T, et al. (2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi: 10.1074/jbc.M103473200 . PMID 11346656.
Thélu J, Rossio P, Favier B (2003). "Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing". BMC Dermatol. 2: 7. doi: 10.1186/1471-5945-2-7 . PMC 111189 . PMID 11978185.
Panin VM, Shao L, Lei L, et al. (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi: 10.1074/jbc.M204445200 . PMID 12036964.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Shao L, Moloney DJ, Haltiwanger R (2003). "Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region". J. Biol. Chem. 278 (10): 7775–82. doi: 10.1074/jbc.M212221200 . PMID 12486116.
Veeraraghavalu K, Pett M, Kumar RV, et al. (2004). "Papillomavirus-Mediated Neoplastic Progression Is Associated with Reciprocal Changes in Jagged1 and Manic Fringe Expression Linked to Notch Activation". J. Virol. 78 (16): 8687–700. doi:10.1128/JVI.78.16.8687-8700.2004. PMC 479091 . PMID 15280477.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100060 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018169 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9878264-5] Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW (Feb 1999). "Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12". Genomics. 54 (3): 576–7. doi:10.1006/geno.1998.5559. PMID 9878264.

[pmid9187150-6] Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF (Jul 1997). "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway". Development. 124 (11): 2245–54. doi:10.1242/dev.124.11.2245. PMID 9187150.

[entrez-7] 1 2 "Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase".

[8] "Troublesome gene names get the boot", 6 November 2006, Michael Hopkin, nature.com

[9] "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

MFNG

Related Research Articles

References

Further reading