MICAL2

MICAL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9K
Identifiers
Aliases	MICAL2 , MICAL-2, MICAL2PV1, MICAL2PV2, microtubule associated monooxygenase, calponin and LIM domain containing 2
External IDs	OMIM: 608881 MGI: 2444947 HomoloGene: 8760 GeneCards: MICAL2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.3 Start 12,094,008 bp [1] End 12,359,144 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F1 Start 112,225,856 bp [2] End 112,413,106 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere endothelial cell Brodmann area 23 middle temporal gyrus right coronary artery saphenous vein ascending aorta frontal pole Region I of hippocampus proper visceral pleura Top expressed in superior frontal gyrus ascending aorta seminiferous tubule aortic valve spermatid cerebellar cortex atrium lip olfactory epithelium pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen FAD binding metal ion binding monooxygenase activity oxidoreductase activity NADPH:sulfur oxidoreductase activity NAD(P)H oxidase H2O2-forming activity Cellular component nucleus Biological process heart looping actin filament depolymerization heart development cytoskeleton organization sulfur oxidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9645 320878 Ensembl ENSG00000133816 ENSMUSG00000038244 UniProt O94851 Q8BML1 RefSeq (mRNA) NM_001282663 NM_001282664 NM_001282665 NM_001282666 NM_001282667 NM_001282668 NM_001346292 NM_001346293 NM_001346294 NM_001346295 NM_001346296 NM_001346297 NM_001346298 NM_001346299 NM_014632 NM_001193305 NM_177282 RefSeq (protein) NP_001269592 NP_001269593 NP_001269594 NP_001269595 NP_001269596 NP_001269597 NP_001333221 NP_001333222 NP_001333223 NP_001333224 NP_001333225 NP_001333226 NP_001333227 NP_001333228 NP_055447 NP_001180234 NP_796256 Location (UCSC) Chr 11: 12.09 – 12.36 Mb Chr 7: 112.23 – 112.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein MICAL-2 is a protein that in humans is encoded by the MICAL2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000133816 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038244 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (Jul 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi: 10.1016/S0092-8674(02)00794-8 . PMID   12110185.
6. "Entrez Gene: MICAL2 microtubule associated monoxygenase, calponin and LIM domain containing 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID   15694364.
• Ashida S, Furihata M, Katagiri T, et al. (2006). "Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression". Clin. Cancer Res. 12 (9): 2767–73. doi: 10.1158/1078-0432.CCR-05-1995 . PMID   16675569.