MICAL3

MICAL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D88
Identifiers
Aliases	MICAL3 , MICAL-3, microtubule associated monooxygenase, calponin and LIM domain containing 3
External IDs	OMIM: 608882; MGI: 2442733; HomoloGene: 85288; GeneCards: MICAL3; OMA:MICAL3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.21 Start 17,787,649 bp [1] End 18,024,561 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F1 Start 120,931,707 bp [2] End 121,130,999 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube right hemisphere of cerebellum apex of heart body of uterus smooth muscle tissue epithelium of colon muscle layer of sigmoid colon left testis left uterine tube Top expressed in cumulus cell lip zygote superior frontal gyrus primary visual cortex muscle of thigh dentate gyrus of hippocampal formation granule cell cerebellar cortex tail of embryo genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function monooxygenase activity oxidoreductase activity actin binding FAD binding metal ion binding protein binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Cellular component plasma membrane cytoskeleton nucleus nucleoplasm cytoplasm cytosol spindle cell cortex midbody cell projection Biological process actin filament depolymerization cytoskeleton organization exocytosis cell cycle cell division Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57553 194401 Ensembl ENSG00000243156 ENSMUSG00000051586 UniProt Q7RTP6 Q8CJ19 RefSeq (mRNA) NM_001122731 NM_001136004 NM_015241 NM_020793 NM_001270475 NM_153396 RefSeq (protein) NP_001116203 NP_001129476 NP_056056 NP_001257404 NP_700445 Location (UCSC) Chr 22: 17.79 – 18.02 Mb Chr 6: 120.93 – 121.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Microtubule-associated monoxygenase, calponin and LIM domain containing 3, also known as MICAL3, is a human gene. ^[5]

Function

Along with two other Rab proteins, Rab6 and Rab8, MICAL3 work together in the process of docking and fusing of vesicles that are involved in exocytosis. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000243156 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051586 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MICAL3 microtubule associated monoxygenase, calponin and LIM domain containing 3".
6. Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, et al. (June 2011). "Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers". Current Biology. 21 (11): 967–974. Bibcode:2011CBio...21..967G. doi: 10.1016/j.cub.2011.04.030 . PMID   21596566. S2CID   7950950.

Further reading

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, et al. (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–364. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, et al. (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (June 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi: 10.1016/S0092-8674(02)00794-8 . PMID   12110185.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Fischer J, Weide T, Barnekow A (March 2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochemical and Biophysical Research Communications. 328 (2): 415–423. doi:10.1016/j.bbrc.2004.12.182. PMID   15694364.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.