MINPP1

MINPP1
Identifiers
Aliases	MINPP1 , HIPER1, MINPP2, MIPP, multiple inositol-polyphosphate phosphatase 1, PCH16
External IDs	OMIM: 605391; MGI: 1336159; HomoloGene: 37980; GeneCards: MINPP1; OMA:MINPP1 - orthologs
EC number	3.1.3.80
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q23.2 Start 87,504,875 bp [1] End 87,553,461 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 C1|19 27.25 cM Start 32,463,169 bp [2] End 32,492,764 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone tibia islet of Langerhans Epithelium of choroid plexus jejunal mucosa right adrenal cortex gonad kidney tubule left adrenal gland stromal cell of endometrium Top expressed in fetal liver hematopoietic progenitor cell abdominal wall primitive streak molar seminal vesicula endocardial cushion skin of back decidua epiblast right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatase activity bisphosphoglycerate 3-phosphatase activity inositol-hexakisphosphate phosphatase activity hydrolase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity inositol hexakisphosphate 2-phosphatase activity acid phosphatase activity inositol phosphate phosphatase activity protein histidine phosphatase activity Cellular component endoplasmic reticulum lumen endoplasmic reticulum extracellular exosome Biological process bone mineralization polyphosphate metabolic process inositol phosphate metabolic process ossification dephosphorylation protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9562 17330 Ensembl ENSG00000107789 ENSMUSG00000024896 UniProt Q9UNW1 Q9Z2L6 RefSeq (mRNA) NM_001178117 NM_001178118 NM_004897 NM_010799 RefSeq (protein) NP_001171588 NP_001171589 NP_004888 NP_034929 Location (UCSC) Chr 10: 87.5 – 87.55 Mb Chr 19: 32.46 – 32.49 Mb PubMed search [3] [4]
Wikidata
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Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene. ^{[5] [6]}

MINPP1 hydrolyzes the abundant metabolites inositol pentakisphosphate and inositol hexakisphosphate and, like PTEN (MIM 601728), has the ability to remove 3-phosphate from inositol phosphate substrates.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000107789 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024896 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR (May 1999). "Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19". Genomics. 56 (3): 324–36. doi: 10.1006/geno.1998.5736 . PMID   10087200.
6. "Entrez Gene: MINPP1 multiple inositol polyphosphate histidine phosphatase, 1".

Further reading

• Romano PR, Wang J, O'Keefe RJ, et al. (1998). "HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation". J. Cell Sci. 111 (6): 803–13. doi:10.1242/jcs.111.6.803. PMID   9472008.
• Caffrey JJ, Hidaka K, Matsuda M, et al. (1999). "The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification". FEBS Lett. 442 (1): 99–104. doi: 10.1016/S0014-5793(98)01636-6 . PMID   9923613. S2CID   7105717.
• Chi H, Yang X, Kingsley PD, et al. (2000). "Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo". Mol. Cell. Biol. 20 (17): 6496–507. doi:10.1128/MCB.20.17.6496-6507.2000. PMC   86124 . PMID   10938126.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Gimm O, Chi H, Dahia PL, et al. (2001). "Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas". J. Clin. Endocrinol. Metab. 86 (4): 1801–5. doi: 10.1210/jcem.86.4.7419 . PMID   11297621.
• VanHouten JN, Asch HL, Asch BB (2001). "Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas". Oncogene. 20 (38): 5366–72. doi:10.1038/sj.onc.1204701. PMID   11536049. S2CID   6474518.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.