MIS18A

MIS18A
Identifiers
Aliases	MIS18A , B28, C21orf45, C21orf46, FASP1, MIS18alpha, hMis18alpha, MIS18 kinetochore protein A
External IDs	OMIM: 618137; MGI: 1913828; HomoloGene: 41294; GeneCards: MIS18A; OMA:MIS18A - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.11 Start 32,268,228 bp [1] End 32,279,049 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C3.3 Start 90,516,200 bp [2] End 90,524,292 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte gonad ventricular zone ganglionic eminence testicle right testis left testis buccal mucosa cell mucosa of sigmoid colon Top expressed in Paneth cell primitive streak endocardial cushion endothelial cell of lymphatic vessel primary oocyte abdominal wall hair follicle condyle cumulus cell atrioventricular junction More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component chromosome nucleoplasm chromosome, centromeric region nucleus chromatin cytosol Biological process cell division regulation of DNA methylation cell cycle chromosome segregation CENP-A containing chromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54069 66578 Ensembl ENSG00000159055 ENSMUSG00000022978 UniProt Q9NYP9 Q9CZJ6 RefSeq (mRNA) NM_018944 NM_025642 RefSeq (protein) NP_061817 NP_079918 Location (UCSC) Chr 21: 32.27 – 32.28 Mb Chr 16: 90.52 – 90.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein Mis18-alpha is a protein that in humans is encoded by the MIS18A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000159055 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022978 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (Jan 2007). "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1". Developmental Cell. 12 (1): 17–30. doi: 10.1016/j.devcel.2006.11.002 . PMID   17199038.
6. "Entrez Gene: C21orf45 chromosome 21 open reading frame 45".

External links

• Human MIS18A genome location and MIS18A gene details page in the UCSC Genome Browser .

Further reading

• Slavov D, Hattori M, Sakaki Y, Rosenthal A, Shimizu N, Minoshima S, Kudoh J, Yaspo ML, Ramser J, Reinhardt R, Reimer C, Clancy K, Rynditch A, Gardiner K (Apr 2000). "Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21". Gene. 247 (1–2): 215–32. doi:10.1016/S0378-1119(00)00089-5. PMID   10773462.
• Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Oct 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". The Biochemical Journal. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC   1221362 . PMID   11001876.
• Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID   12036298.
• Ye XX, Lu H, Yu Y, Ding N, Zhang NL, Huo KK, Wan DF, Li YY, Gu JR (Mar 2005). "P5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1". Molecular and Cellular Biochemistry. 271 (1–2): 151–8. doi:10.1007/s11010-005-5907-6. PMID   15881666. S2CID   2101296.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.