MK6892

MK6892

Identifiers
IUPAC name 2-[[3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoyl]amino]cyclohexene-1-carboxylic acid
CAS Number	917910-45-3
PubChem CID	135416394
IUPHAR/BPS	5788
ChemSpider	24664360
UNII	PH9ZB6IRW0
ChEMBL	ChEMBL1086657
Chemical and physical data
Formula	C19H22N4O5
Molar mass	386.408 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(CC1=NC(=NO1)C2=NC=C(C=C2)O)C(=O)NC3=C(CCCC3)C(=O)O
InChI InChI=1S/C19H22N4O5/c1-19(2,18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8,10,24H,3-6,9H2,1-2H3,(H,21,27)(H,25,26) Key:CJHXBFSJXDUJHP-UHFFFAOYSA-N

MK6892 is an experimental drug which acts as a potent and selective agonist for the Hydroxycarboxylic acid receptor 2 (GPR109A). It has been investigated for lowering blood lipid levels and potential applications in the treatment of colon cancer. ^{[1] [2] [3] [4]}

References

1. Shen HC, Ding FX, Raghavan S, Deng Q, Luell S, Forrest MJ, et al. (March 2010). "Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate". Journal of Medicinal Chemistry. 53 (6): 2666–2670. doi:10.1021/jm100022r. PMID   20184326.
2. Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, et al. (March 2023). "Structural insights into the human niacin receptor HCA2-G_i signalling complex". Nature Communications. 14 (1) 1692. Bibcode:2023NatCo..14.1692Y. doi:10.1038/s41467-023-37177-6. PMC   10043007 . PMID   36973264.
3. Li N, Niu L, Liu Y, Wang Y, Su X, Xu C, et al. (May 2024). "Taking SCFAs produced by Lactobacillus reuteri orally reshapes gut microbiota and elicits antitumor responses". Journal of Nanobiotechnology. 22 (1) 241. doi: 10.1186/s12951-024-02506-4 . PMC   11089779 . PMID   38735933.
4. Wang J, Qian Y, Han Z, Wang Y, Liu Y, Li J, et al. (February 2025). "Insights into the Activation Mechanism of HCA1, HCA2, and HCA3". Journal of Medicinal Chemistry. 68 (4): 4527–4539. doi:10.1021/acs.jmedchem.4c02567. PMC   11873900 . PMID   39936872.