MLF1

MLF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UAL, 3UBW
Identifiers
Aliases	MLF1 , myeloid leukemia factor 1
External IDs	OMIM: 601402 MGI: 1341819 HomoloGene: 7839 GeneCards: MLF1
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q25.32 Start 158,571,163 bp [1] End 158,607,252 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 E1|3 30.91 cM Start 67,281,430 bp [2] End 67,307,336 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm bronchial epithelial cell myocardium right ventricle biceps brachii right uterine tube left ventricle triceps brachii muscle vastus lateralis muscle body of tongue Top expressed in spermatid triceps brachii muscle sternocleidomastoid muscle temporal muscle seminiferous tubule spermatocyte digastric muscle intercostal muscle masseter muscle quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein domain specific binding DNA binding Cellular component nucleus cytoplasm cytoskeleton cilium ciliary basal body cell projection Biological process multicellular organism development cell cycle cell differentiation myeloid progenitor cell differentiation transcription, DNA-templated regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4291 17349 Ensembl ENSG00000178053 ENSMUSG00000048416 UniProt P58340 Q9QWV4 RefSeq (mRNA) NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443 NM_001369781 NM_001369782 NM_001369783 NM_001369784 NM_001369785 NM_001039543 NM_010801 RefSeq (protein) NP_001123628 NP_001123629 NP_001182361 NP_001182362 NP_001182363 NP_071888 NP_001356710 NP_001356711 NP_001356712 NP_001356713 NP_001356714 NP_001365774 NP_001365775 NP_001365776 NP_001365777 NP_001365779 NP_001365780 NP_001365781 NP_001365782 NP_001365784 NP_001034632 NP_034931 Location (UCSC) Chr 3: 158.57 – 158.61 Mb Chr 3: 67.28 – 67.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myeloid leukemia factor 1 is a protein that in humans is encoded by the MLF1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000178053 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048416 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW (Mar 1996). "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1". Oncogene. 12 (2): 265–75. PMID   8570204.
6. "Entrez Gene: MLF1 myeloid leukemia factor 1".

Further reading

• Lim R, Winteringham LN, Williams JH, et al. (2002). "MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1" (PDF). J. Biol. Chem. 277 (43): 40997–1008. doi: 10.1074/jbc.M206041200 . PMID   12176995. S2CID   40077371.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Arber DA, Chang KL, Lyda MH, et al. (2003). "Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia". Hum. Pathol. 34 (8): 809–13. doi: 10.1016/S0046-8177(03)00251-X . PMID   14506644.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Hanissian SH, Akbar U, Teng B, et al. (2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi: 10.1038/sj.onc.1207448 . PMID   15116101.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yoneda-Kato N, Tomoda K, Umehara M, et al. (2005). "Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3". EMBO J. 24 (9): 1739–49. doi:10.1038/sj.emboj.7600656. PMC   1142586 . PMID   15861129.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Yoneda-Kato N, Kato JY (2008). "Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation". Mol. Cell. Biol. 28 (1): 422–34. doi:10.1128/MCB.02335-06. PMC   2223285 . PMID   17967869.