MLF1IP

CENPU
Identifiers
Aliases	CENPU , CENP50, CENPU50, KLIP1, MLF1IP, PBIP1, centromere protein U
External IDs	OMIM: 611511; MGI: 1919126; HomoloGene: 11629; GeneCards: CENPU; OMA:CENPU - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q35.1 Start 184,694,085 bp [1] End 184,734,130 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B1.1 Start 47,005,063 bp [2] End 47,033,042 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm oocyte secondary oocyte right testis left testis trabecular bone ventricular zone embryo ganglionic eminence bone marrow Top expressed in spermatocyte spermatid tail of embryo zygote seminiferous tubule secondary oocyte genital tubercle hand yolk sac epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component chromosome cytoplasm cytosol chromosome, centromeric region nucleus kinetochore nucleoplasm microtubule organizing center Biological process chordate embryonic development viral process regulation of transcription, DNA-templated CENP-A containing chromatin assembly transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79682 71876 Ensembl ENSG00000151725 ENSMUSG00000031629 UniProt Q71F23 Q8C4M7 RefSeq (mRNA) NM_024629 NM_027973 NM_001368403 RefSeq (protein) NP_078905 NP_082249 NP_001355332 Location (UCSC) Chr 4: 184.69 – 184.73 Mb Chr 8: 47.01 – 47.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein U is a protein that in humans is encoded by the CENPU gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000151725 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031629 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW (Apr 2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID   15116101. S2CID   1627133.
6. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID   16622420. S2CID   26974412.
7. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID   16622419. S2CID   205286556.
8. "Entrez Gene: MLF1IP MLF1 interacting protein".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Zhang YJ, Pan HY, Gao SJ (2002). "Reverse transcription slippage over the mRNA secondary structure of the LIP1 gene". BioTechniques. 31 (6): 1286–1294. doi: 10.2144/01316st02 . PMID   11768657.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Pan HY, Zhang YJ, Wang XP, et al. (2003). "Identification of a Novel Cellular Transcriptional Repressor Interacting with the Latent Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus". J. Virol. 77 (18): 9758–68. doi:10.1128/JVI.77.18.9758-9768.2003. PMC   224565 . PMID   12941884.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID   15009096. S2CID   21813024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hanissian SH, Teng B, Akbar U, et al. (2005). "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma". Brain Res. 1047 (1): 56–64. doi:10.1016/j.brainres.2005.04.017. PMID   15893739. S2CID   30594722.
• Minoshima Y, Hori T, Okada M, et al. (2005). "The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage". Mol. Cell. Biol. 25 (23): 10315–28. doi:10.1128/MCB.25.23.10315-10328.2005. PMC   1291240 . PMID   16287847.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID   16716197. S2CID   45931410.
• Kang YH, Park JE, Yu LR, et al. (2006). "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation". Mol. Cell. 24 (3): 409–22. doi: 10.1016/j.molcel.2006.10.016 . PMID   17081991.
• Suzuki H, Arakawa Y, Ito M, et al. (2007). "MLF1-interacting protein is mainly localized in nucleolus through N-terminal bipartite nuclear localization signal". Anticancer Res. 27 (3B): 1423–30. PMID   17595757.