MLF1IP

CENPU
Identifiers
Aliases	CENPU , CENP50, CENPU50, KLIP1, MLF1IP, PBIP1, centromere protein U
External IDs	OMIM: 611511 MGI: 1919126 HomoloGene: 11629 GeneCards: CENPU
Gene location (Human)
Chr.	Chromosome 4 (human)
End	184,734,130 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	47,033,042 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; secondary oocyte; ; cancellous bone; ; embryo; ; ganglionic eminence; ; bone marrow; ; amniotic fluid; ; hair follicle; ; cavity of mouth;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; secondary oocyte; ; hand; ; yolk sac; ; blastocyst; ; medial ganglionic eminence; ; morula; ; primitive streak;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	chromosome ; cytoplasm ; cytosol ; chromosome, centromeric region ; nucleus ; kinetochore ; nucleoplasm ; microtubule organizing center ;
Biological process	chordate embryonic development ; viral process ; regulation of transcription, DNA-templated ; CENP-A containing chromatin assembly ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	79682
	71876
	ENSG00000151725
	ENSMUSG00000031629
	Q71F23
	Q8C4M7
	NM_024629
	NM_027973 ; NM_001368403
	NP_078905
	NP_082249 ; NP_001355332
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Centromere protein U is a protein that in humans is encoded by the CENPU gene.^[5]^[6]^[7]^[8]

Related Research Articles

<span class="mw-page-title-main">Centromere</span> Specialized DNA sequence of a chromosome that links a pair of sister chromatids

The centromere links a pair of sister chromatids together during cell division. This constricted region of chromosome connects the sister chromatids, creating a short arm (p) and a long arm (q) on the chromatids. During mitosis, spindle fibers attach to the centromere via the kinetochore.

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome in most eukaryotes including humans.

E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.

Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 is an enzyme that in humans is encoded by the DHX38 gene.

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.

Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

Zinc finger CCCH domain-containing protein 13 is a protein that in humans is encoded by the ZC3H13 gene.

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.

Centromere protein T is a protein that in humans is encoded by the CENPT gene.

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.

Centromere protein N is a protein that in humans is encoded by the CENPN gene.

Centromere protein L is a protein that in humans is encoded by the CENPL gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151725 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031629 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW (Apr 2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.
↑ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
↑ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
↑ "Entrez Gene: MLF1IP MLF1 interacting protein".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Zhang YJ, Pan HY, Gao SJ (2002). "Reverse transcription slippage over the mRNA secondary structure of the LIP1 gene". BioTechniques. 31 (6): 1286–1294. doi: 10.2144/01316st02 . PMID 11768657.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Pan HY, Zhang YJ, Wang XP, et al. (2003). "Identification of a Novel Cellular Transcriptional Repressor Interacting with the Latent Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus". J. Virol. 77 (18): 9758–68. doi:10.1128/JVI.77.18.9758-9768.2003. PMC 224565 . PMID 12941884.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID 15009096. S2CID 21813024.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hanissian SH, Teng B, Akbar U, et al. (2005). "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma". Brain Res. 1047 (1): 56–64. doi:10.1016/j.brainres.2005.04.017. PMID 15893739. S2CID 30594722.
Minoshima Y, Hori T, Okada M, et al. (2005). "The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage". Mol. Cell. Biol. 25 (23): 10315–28. doi:10.1128/MCB.25.23.10315-10328.2005. PMC 1291240 . PMID 16287847.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID 16716197. S2CID 45931410.
Kang YH, Park JE, Yu LR, et al. (2006). "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation". Mol. Cell. 24 (3): 409–22. doi: 10.1016/j.molcel.2006.10.016 . PMID 17081991.
Suzuki H, Arakawa Y, Ito M, et al. (2007). "MLF1-interacting protein is mainly localized in nucleolus through N-terminal bipartite nuclear localization signal". Anticancer Res. 27 (3B): 1423–30. PMID 17595757.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151725 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031629 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15116101-5] Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW (Apr 2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.

[pmid16622420-6] Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.

[pmid16622419-7] Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.

[entrez-8] "Entrez Gene: MLF1IP MLF1 interacting protein".

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MLF1IP

Related Research Articles

References

Further reading