Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene. [4] [5]
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [5]
Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the Bcl-2 gene family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.
The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains, and can form hetero- or homodimers. Bcl-2 proteins act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.
Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.
FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.
Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene. This gene encodes a protein with an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.
Zinc finger MYND domain-containing protein 10 is a protein that in humans is encoded by the ZMYND10 gene.
Activator of apoptosis harakiri is a protein that in humans is encoded by the HRK gene.
Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.
Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.
Bcl-2-modifying factor is a protein that in humans is encoded by the BMF gene.
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.
Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.
Autophagy related 12 is a protein that in humans is encoded by the ATG12 gene.
BAG family molecular chaperone regulator 4 is a protein that in humans is encoded by the BAG4 gene.
Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene.
39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.
RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.
Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene.
BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.
Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.
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