MOGAT3

MOGAT3
Identifiers
Aliases	MOGAT3 , DC7, DGAT2L7, MGAT3, DGAT2L2, monoacylglycerol O-acyltransferase 3
External IDs	OMIM: 610184 HomoloGene: 80517 GeneCards: MOGAT3
Gene location (Human)
Chr.	Chromosome 7 (human)
End	101,201,038 bp
RNA expression pattern
	Top expressed in
	rectum; ; right lobe of liver; ; duodenum; ; jejunal mucosa; ; appendix; ; kidney; ; smooth muscle tissue; ; blood; ; fundus; ; islet of Langerhans;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	acyltransferase activity ; acyltransferase activity, transferring groups other than amino-acyl groups ; transferase activity ; diacylglycerol O-acyltransferase activity ; 2-acylglycerol O-acyltransferase activity ;
Cellular component	membrane ; integral component of membrane ; endoplasmic reticulum ; endoplasmic reticulum membrane ;
Biological process	lipid metabolism ; glycerol metabolic process ; triglyceride biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	346606
	n/a
	ENSG00000106384
	n/a
	Q86VF5
	n/a
	NM_001287147 ; NM_178176
	n/a
	NP_001274076 ; NP_835470
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Monoacylglycerol O-acyltransferase 3 is a protein that in humans is encoded by the MOGAT3 gene.^[3]

Function

Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA.^[4]

Related Research Articles

Lecithin–cholesterol acyltransferase is an enzyme, in many animals including humans, that converts free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma. LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage. It belongs to the family of phospholipid:diacylglycerol acyltransferases.

Sterol O-acyltransferase 1, also known as SOAT1, is an enzyme that in humans is encoded by the SOAT1 gene.

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase beta is an enzyme that in humans is encoded by the AGPAT2 gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.

Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.

Lysophospholipid acyltransferase 5 is an enzyme that in humans is encoded by the LPCAT3 gene. It is homologous to other membrane-bound O-acyltransferases.

Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the GPAM gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that in humans is encoded by the AGPAT5 gene.

Glycine-N-acyltransferase, also known as GLYAT, is an enzyme which in humans is encoded by the GLYAT gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene. The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene.

Peroxisomal carnitine O-octanoyltransferase is an enzyme that in humans is encoded by the CROT gene.

2-Acylglycerol O-acyltransferase 2 also known as acyl-CoA:monoacylglycerol acyltransferase 2 (MGAT2) or Diacylglycerol O-acyltransferase candidate 5 (DC5) is an enzyme that in humans is encoded by the MOGAT2 gene.

Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene. GPAT-3 is also known as:

Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.

Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 gene

Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene. It is homologous to other membrane-bound O-acyltransferases.

Diacylglycerol O-acyltransferase 1 is an enzyme that in humans is encoded by the DGAT1 gene.

Diacylglycerol O-acyltransferase 2 (DGAT2) is a protein that in humans is encoded by the DGAT2 gene.

Glycerol-3-phosphate acyltransferase 4 is a protein that in humans is encoded by the GPAT4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106384 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Monoacylglycerol O-acyltransferase 3".
↑ Cheng D, Nelson TC, Chen J, Walker SG, Wardwell-Swanson J, Meegalla R, Taub R, Billheimer JT, Ramaker M, Feder JN (Apr 2003). "Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption". The Journal of Biological Chemistry. 278 (16): 13611–4. doi: 10.1074/jbc.C300042200 . PMID 12618427.

MOGAT3

Contents

Function

Related Research Articles

References

Further reading