MORC2

MORC2
Identifiers
Aliases	MORC2 , ZCW3, ZCWCC1, CMT2Z, MORC family CW-type zinc finger 2, DIGFAN
External IDs	OMIM: 616661; MGI: 1921772; HomoloGene: 8966; GeneCards: MORC2; OMA:MORC2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.2 Start 30,925,130 bp [1] End 30,968,774 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A1 Start 3,599,191 bp [2] End 3,640,477 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis ganglionic eminence endothelial cell stromal cell of endometrium saphenous vein ventricular zone testicle gastric mucosa Top expressed in tail of embryo genital tubercle superior cervical ganglion hand zygote spermatocyte otolith organ utricle spermatid epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding protein binding magnesium ion binding chromatin binding ATP binding ATPase activity protein homodimerization activity nucleotide binding hydrolase activity Cellular component nucleus cytoplasm cytosol heterochromatin nuclear matrix chromosome Biological process fatty acid metabolic process lipid metabolism cellular response to DNA damage stimulus negative regulation of gene expression, epigenetic negative regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of DNA methylation-dependent heterochromatin assembly chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22880 74522 Ensembl ENSG00000133422 ENSMUSG00000034543 UniProt Q9Y6X9 Q69ZX6 RefSeq (mRNA) NM_001303256 NM_001303257 NM_014941 NM_001159288 NM_198162 NM_001363202 RefSeq (protein) NP_001290185 NP_001290186 NP_055756 NP_001152760 NP_937805 NP_001350131 Location (UCSC) Chr 22: 30.93 – 30.97 Mb Chr 11: 3.6 – 3.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MORC family CW-type zinc finger protein 2 is a protein that in humans is encoded by the MORC2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000133422 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034543 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Perry J, Zhao Y (Nov 2003). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants". Trends Biochem Sci. 28 (11): 576–80. doi:10.1016/j.tibs.2003.09.007. PMID   14607086.
6. "Entrez Gene: MORC2 MORC family CW-type zinc finger 2".

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.