MORF4L1

Last updated
MORF4L1
Protein MORF4L1 PDB 2aql.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MORF4L1 , Eaf3, HsT17725, MEAF3, MORFRG15, MRG15, S863-6, FWP006, mortality factor 4 like 1
External IDs OMIM: 607303 MGI: 1096551 HomoloGene: 86043 GeneCards: MORF4L1
Gene location (Human)
Ideogram human chromosome 15.svg
Chr. Chromosome 15 (human) [1]
Human chromosome 15 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 15q25.1Start78,810,487 bp [1]
End78,898,139 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_206839
NM_001265603
NM_001265604
NM_001265605
NM_006791

Contents

NM_001039147
NM_024431
NM_001357780

RefSeq (protein)

NP_001252532
NP_001252533
NP_001252534
NP_006782
NP_996670

NP_001034236
NP_077751
NP_001344709

Location (UCSC) Chr 15: 78.81 – 78.9 Mb Chr 9: 90.09 – 90.11 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mortality factor 4-like protein 1 is a protein that in humans is encoded by the MORF4L1 gene. [5] [6] [7]

Interactions

MORF4L1 has been shown to interact with MYST1, [8] Retinoblastoma protein [8] [9] and MRFAP1. [8] [9]

Related Research Articles

CREB-binding protein Nuclear protein that binds to CREB

CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene. The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more CREB domains: the nuclear receptor interaction domain (RID), the KIX domain, the cysteine/histidine regions and the interferon response binding domain (IBiD). The CREB protein domains, KIX, TAZ1 and TAZ2, each bind tightly to a sequence spanning both transactivation domains 9aaTADs of transcription factor p53.

HDAC1

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

STAT2

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family.

E2F1

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

CREB1

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

SIN3A

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.

ETS2

Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.

RUVBL2

RuvB-like 2 , also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

HSPA4

Heat shock 70 kDa protein 4 is a protein that in humans is encoded by the HSPA4 gene.

GTF2I

General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene.

SIN3B

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.

CITED2

Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.

MORF4L2

Mortality factor 4-like protein 2 is a protein that in humans is encoded by the MORF4L2 gene.

KAT8

K(lysine) acetyltransferase 8 (KAT8) is an enzyme that in humans is encoded by the KAT8 gene.

ZNF350

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.

SNAPC3

snRNA-activating protein complex subunit 3 is a protein that in humans is encoded by the SNAPC3 gene.

SNAPC2

snRNA-activating protein complex subunit 2 is a protein that in humans is encoded by the SNAPC2 gene.

SNAPC4

snRNA-activating protein complex subunit 4 is a protein that in humans is encoded by the SNAPC4 gene.

MRFAP1

MORF4 family-associated protein 1 is a protein that in humans is encoded by the MRFAP1 gene.

KIX domain

In biochemistry, the KIX domain (kinase-inducible domain (KID) interacting domain) or CREB binding domain is a protein domain of the eukaryotic transcriptional coactivators CBP and P300. It serves as a docking site for the formation of heterodimers between the coactivator and specific transcription factors. Structurally, the KIX domain is a globular domain consisting of three α-helices and two short 310-helices.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000185787 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062270 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
  6. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
  7. "Entrez Gene: MORF4L1 mortality factor 4 like 1".
  8. 1 2 3 Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (Dec 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". The Journal of Biological Chemistry. 277 (52): 50860–6. doi: 10.1074/jbc.M203839200 . PMID   12397079.
  9. 1 2 Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM (Oct 2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14". The Journal of Biological Chemistry. 276 (42): 39171–8. doi: 10.1074/jbc.M103435200 . PMID   11500496.

Further reading