MRFAP1

MRFAP1
Identifiers
Aliases	MRFAP1 , PAM14, PGR1, Morf4 family associated protein 1, PGR1`
External IDs	OMIM: 616905; MGI: 1914818; HomoloGene: 128357; GeneCards: MRFAP1; OMA:MRFAP1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.1 Start 6,640,091 bp [1] End 6,642,729 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B3 Start 36,952,211 bp [2] End 36,954,116 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pancreatic epithelial cell Brodmann area 23 parietal pleura middle temporal gyrus visceral pleura germinal epithelium pons postcentral gyrus superior vestibular nucleus Top expressed in hippocampus proper olfactory bulb epiblast adrenal gland islet of Langerhans ventricular zone hypothalamus uterus placenta lens More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 93621 67568 Ensembl ENSG00000179010 ENSMUSG00000055302 UniProt Q9Y605 Q9CQL7 RefSeq (mRNA) NM_033296 NM_001272053 NM_001272054 NM_026242 RefSeq (protein) NP_001258982 NP_001258983 NP_150638 NP_080518 Location (UCSC) Chr 4: 6.64 – 6.64 Mb Chr 5: 36.95 – 36.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MORF4 family-associated protein 1 is a protein that in humans is encoded by the MRFAP1 gene. ^{[5] [6]}

Interactions

MRFAP1 has been shown to interact with MORF4L1 ^{[7] [8]} and Retinoblastoma protein. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000179010 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055302 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM (Oct 2004). "PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice". Molecular and Cellular Biology. 24 (19): 8366–73. doi:10.1128/MCB.24.19.8366-8373.2004. PMC   516751 . PMID   15367658.
6. "Entrez Gene: MRFAP1 Mof4 family associated protein 1".
7. Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM (Oct 2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14". The Journal of Biological Chemistry. 276 (42): 39171–8. doi: 10.1074/jbc.M103435200 . PMID   11500496.
8. Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (Dec 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". The Journal of Biological Chemistry. 277 (52): 50860–6. doi: 10.1074/jbc.M203839200 . PMID   12397079.

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Zhang P, Zhao J, Wang B, Du J, Lu Y, Chen J, Ding J (Oct 2006). "The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14". Protein Science. 15 (10): 2423–34. doi:10.1110/ps.062397806. PMC   2242394 . PMID   17008723.
• Tominaga K, Leung JK, Rookard P, Echigo J, Smith JR, Pereira-Smith OM (Dec 2003). "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner". The Journal of Biological Chemistry. 278 (49): 49618–24. doi: 10.1074/jbc.M309192200 . PMID   14506250.
• Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM (Dec 2002). "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation". The Journal of Biological Chemistry. 277 (52): 50860–6. doi: 10.1074/jbc.M203839200 . PMID   12397079.
• Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM (Oct 2001). "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14". The Journal of Biological Chemistry. 276 (42): 39171–8. doi: 10.1074/jbc.M103435200 . PMID   11500496.