MORF4L2

MORF4L2
Identifiers
Aliases	MORF4L2 , MORFL2, MRGX, mortality factor 4 like 2
External IDs	OMIM: 300409 MGI: 1927167 HomoloGene: 22710 GeneCards: MORF4L2
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.2 Start 103,675,496 bp [1] End 103,688,158 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F1 Start 135,633,691 bp [2] End 135,644,439 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell caput epididymis bronchial epithelial cell pons postcentral gyrus Brodmann area 23 seminal vesicula corpus epididymis superior vestibular nucleus tibia Top expressed in yolk sac placenta mesencephalon neural tube mirror islet of Langerhans uterus ganglionic eminence hippocampus proper hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component plasma membrane nucleolus nucleus nucleoplasm NuA4 histone acetyltransferase complex histone acetyltransferase complex Biological process histone H2A acetylation chromatin remodeling regulation of growth regulation of transcription, DNA-templated histone deacetylation DNA repair transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of striated muscle cell differentiation cellular response to DNA damage stimulus histone H4 acetylation chromatin organization histone acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9643 56397 Ensembl ENSG00000123562 ENSMUSG00000031422 UniProt Q15014 Q9R0Q4 RefSeq (mRNA) NM_012286 NM_001142418 NM_001142419 NM_001142420 NM_001142421 NM_001142422 NM_001142423 NM_001142424 NM_001142425 NM_001142426 NM_001142427 NM_001142428 NM_001142429 NM_001142430 NM_001142431 NM_001142432 NM_001168225 NM_001168226 NM_001168227 NM_001168228 NM_001168229 NM_001168230 NM_019768 RefSeq (protein) NP_001135890 NP_001135891 NP_001135892 NP_001135893 NP_001135894 NP_001135895 NP_001135896 NP_001135897 NP_001135898 NP_001135899 NP_001135900 NP_001135901 NP_001135902 NP_001135903 NP_001135904 NP_036418 NP_001161697 NP_001161698 NP_001161699 NP_001161700 NP_001161701 NP_001161702 NP_062742 Location (UCSC) Chr X: 103.68 – 103.69 Mb Chr X: 135.63 – 135.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mortality factor 4-like protein 2 is a protein that in humans is encoded by the MORF4L2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000123562 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031422 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bertram MJ, Berube NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM (Feb 1999). "Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes". Mol Cell Biol. 19 (2): 1479–85. doi:10.1128/mcb.19.2.1479. PMC   116076 . PMID   9891081.
6. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
7. "Entrez Gene: MORF4L2 mortality factor 4 like 2".

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID   10942595.
• Sakai K, Shirakawa T, Li Y, et al. (2002). "Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X". Mol. Cell. Neurosci. 19 (4): 477–84. doi:10.1006/mcne.2001.1059. PMID   11988016. S2CID   26659745.
• Yochum GS, Ayer DE (2002). "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC   134742 . PMID   12391155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi: 10.1074/jbc.C300389200 . PMID   12963728.
• Tominaga K, Leung JK, Rookard P, et al. (2004). "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner". J. Biol. Chem. 278 (49): 49618–24. doi: 10.1074/jbc.M309192200 . PMID   14506250.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi: 10.1074/jbc.M500001200 . PMID   15647280.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.