MPZL1

MPZL1
Identifiers
Aliases	MPZL1 , MPZL1b, PZR, PZR1b, PZRa, PZRb, myelin protein zero like 1
External IDs	OMIM: 604376; MGI: 1915731; HomoloGene: 2939; GeneCards: MPZL1; OMA:MPZL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q24.2 Start 167,721,192 bp [1] End 167,791,919 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H2.3 Start 165,419,809 bp [2] End 165,462,107 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gallbladder rectum smooth muscle tissue minor salivary glands islet of Langerhans left uterine tube gastric mucosa epithelium of colon right coronary artery Top expressed in otolith organ utricle hand vestibular sensory epithelium cervix external carotid artery vas deferens Gonadal ridge superior cervical ganglion internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural molecule activity Cellular component integral component of membrane cell surface integral component of plasma membrane membrane focal adhesion Biological process cell-cell signaling signal transduction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9019 68481 Ensembl ENSG00000197965 ENSMUSG00000026566 UniProt O95297 Q3TEW6 RefSeq (mRNA) NM_024569 NM_001146191 NM_003953 NM_001001880 NM_001083897 NM_001347128 RefSeq (protein) NP_001139663 NP_003944 NP_078845 NP_003944.1 NP_001001880 NP_001077366 NP_001334057 Location (UCSC) Chr 1: 167.72 – 167.79 Mb Chr 1: 165.42 – 165.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myelin protein zero-like protein 1 is a protein that in humans is encoded by the MPZL1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000197965 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026566 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhao ZJ, Zhao R (Dec 1998). "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2". J Biol Chem. 273 (45): 29367–72. doi: 10.1074/jbc.273.45.29367 . PMID   9792637.
6. "Entrez Gene: MPZL1 myelin protein zero-like 1".

Further reading

• Zhao R, Zhao ZJ (2000). "Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs". J. Biol. Chem. 275 (8): 5453–9. doi: 10.1074/jbc.275.8.5453 . PMID   10681522.
• Zhao R, Guerrah A, Tang H, Zhao ZJ (2002). "Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling". J. Biol. Chem. 277 (10): 7882–8. doi: 10.1074/jbc.M111914200 . PMID   11751924.
• Tang DS, Yu KP, Tang XX, et al. (2000). "Cloning of Human Myelin Protein Zero-like Genes by Bioinformatics Strategy". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 32 (4): 364–368. PMID   12075424.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID   12107410.
• Zannettino AC, Roubelakis M, Welldon KJ, et al. (2003). "Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration". Biochem. J. 370 (Pt 2): 537–49. doi:10.1042/BJ20020935. PMC   1223174 . PMID   12410637.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhao R, Zhao ZJ (2003). "Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs". Biochem. Biophys. Res. Commun. 303 (4): 1028–33. doi:10.1016/S0006-291X(03)00484-4. PMID   12684038.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Blanchetot C, Chagnon M, Dubé N, et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods. 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID   15588985.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• He G, Liu X, Qin W, et al. (2006). "MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese". Mol. Psychiatry. 11 (8): 748–51. doi: 10.1038/sj.mp.4001841 . PMID   16702974.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.