MPZL1

MPZL1
Identifiers
Aliases	MPZL1 , MPZL1b, PZR, PZR1b, PZRa, PZRb, myelin protein zero like 1
External IDs	OMIM: 604376 MGI: 1915731 HomoloGene: 2939 GeneCards: MPZL1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	167,791,919 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,462,107 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gallbladder; ; rectum; ; smooth muscle tissue; ; minor salivary gland; ; islet of Langerhans; ; left uterine tube; ; gastric mucosa; ; right coronary artery; ; ganglionic eminence;
	Top expressed in
	otolith organ; ; utricle; ; hand; ; cervix; ; external carotid artery; ; vas deferens; ; superior cervical ganglion; ; internal carotid artery; ; stria vascularis; ; medullary collecting duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; structural molecule activity ;
Cellular component	integral component of membrane ; cell surface ; integral component of plasma membrane ; membrane ; focal adhesion ;
Biological process	cell-cell signaling ; signal transduction ; transmembrane receptor protein tyrosine kinase signaling pathway ; positive regulation of cell migration ;
	Sources:Amigo / QuickGO
Orthologs
	9019
	68481
	ENSG00000197965
	ENSMUSG00000026566
	O95297
	Q3TEW6
	NM_024569 ; NM_001146191 ; NM_003953
	NM_001001880 ; NM_001083897 ; NM_001347128
	NP_001139663 ; NP_003944 ; NP_078845 ; NP_003944.1
	NP_001001880 ; NP_001077366 ; NP_001334057
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Myelin protein zero-like protein 1 is a protein that in humans is encoded by the MPZL1 gene.^[5]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197965 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026566 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhao ZJ, Zhao R (Dec 1998). "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2". J Biol Chem. 273 (45): 29367–72. doi: 10.1074/jbc.273.45.29367 . PMID 9792637.
↑ "Entrez Gene: MPZL1 myelin protein zero-like 1".

Zhao R, Zhao ZJ (2000). "Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs". J. Biol. Chem. 275 (8): 5453–9. doi: 10.1074/jbc.275.8.5453 . PMID 10681522.
Zhao R, Guerrah A, Tang H, Zhao ZJ (2002). "Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling". J. Biol. Chem. 277 (10): 7882–8. doi: 10.1074/jbc.M111914200 . PMID 11751924.
Tang DS, Yu KP, Tang XX, et al. (2000). "Cloning of Human Myelin Protein Zero-like Genes by Bioinformatics Strategy". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 32 (4): 364–368. PMID 12075424.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Zannettino AC, Roubelakis M, Welldon KJ, et al. (2003). "Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration". Biochem. J. 370 (Pt 2): 537–49. doi:10.1042/BJ20020935. PMC 1223174 . PMID 12410637.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Zhao R, Zhao ZJ (2003). "Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs". Biochem. Biophys. Res. Commun. 303 (4): 1028–33. doi:10.1016/S0006-291X(03)00484-4. PMID 12684038.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147 . PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Blanchetot C, Chagnon M, Dubé N, et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods. 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.
He G, Liu X, Qin W, et al. (2006). "MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese". Mol. Psychiatry. 11 (8): 748–51. doi: 10.1038/sj.mp.4001841 . PMID 16702974.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197965 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026566 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9792637-5] Zhao ZJ, Zhao R (Dec 1998). "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2". J Biol Chem. 273 (45): 29367–72. doi: 10.1074/jbc.273.45.29367 . PMID 9792637.

[entrez-6] "Entrez Gene: MPZL1 myelin protein zero-like 1".

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MPZL1

Related Research Articles

References

Further reading