MRVI1

IRAG1
Identifiers
Aliases	IRAG1 , IRAG, JAW1L, murine retrovirus integration site 1 homolog, MRVI1, inositol 1,4,5-triphosphate receptor associated 1
External IDs	OMIM: 604673 MGI: 1338023 HomoloGene: 4425 GeneCards: IRAG1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 10,573,091 bp [1] End 10,693,988 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 E3|7 57.9 cM Start 110,467,473 bp [2] End 110,581,668 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein urethra right coronary artery ascending aorta vena cava popliteal artery external globus pallidus cardia left coronary artery gastric mucosa Top expressed in ascending aorta iris aortic valve uterus vas deferens blood Paneth cell conjunctival fornix cervix belly cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm perinuclear region of cytoplasm integral component of membrane platelet dense tubular network membrane endoplasmic reticulum membrane membrane sarcoplasmic reticulum Biological process blood coagulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10335 17540 Ensembl ENSG00000072952 ENSMUSG00000005611 UniProt Q9Y6F6 Q9WUX5 RefSeq (mRNA) NM_130385 NM_001098579 NM_001100163 NM_001100167 NM_001206880 NM_001206881 NM_010826 NM_194464 RefSeq (protein) NP_001092049 NP_001093633 NP_001093637 NP_001193809 NP_001193810 NP_569056 NP_034956 NP_919446 Location (UCSC) Chr 11: 10.57 – 10.69 Mb Chr 7: 110.47 – 110.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein MRVI1 is a protein that in humans is encoded by the MRVI1 gene. ^{[5] [6]}

Function

This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site. ^[6]

Interactions

MRVI1 has been shown to interact with ITPR1 ^[7] and PRKG1. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000072952 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005611 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shaughnessy JD, Largaespada DA, Tian E, Fletcher CF, Cho BC, Vyas P, Jenkins NA, Copeland NG (June 1999). "Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1". Oncogene. 18 (12): 2069–84. doi: 10.1038/sj.onc.1202419 . PMID   10321731.
6. "Entrez Gene: MRVI1 murine retrovirus integration site 1 homolog".
7. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (March 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID   10724174. S2CID   205004996.
8. Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (June 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. 276 (26): 24153–9. doi: 10.1074/jbc.M101530200 . PMID   11309393.

Further reading

• Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. doi:10.1038/355632a0. PMID   1538749. S2CID   4234345.
• Baltensperger K, Chiesi M, Carafoli E (1990). "Substrates of cGMP kinase in vascular smooth muscle and their role in the relaxation process". Biochemistry. 29 (41): 9753–60. doi:10.1021/bi00493a035. PMID   2271613.
• Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID   10724174. S2CID   205004996.
• Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. 276 (26): 24153–9. doi: 10.1074/jbc.M101530200 . PMID   11309393.
• Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P, Hofmann F (2003). "Association of phospholamban with a cGMP kinase signaling complex". Biochem. Biophys. Res. Commun. 300 (1): 155–60. doi:10.1016/S0006-291X(02)02799-7. PMID   12480535.
• Fritsch RM, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhöringer A, Hofmann F, Allescher HD (2004). "InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle". J. Biol. Chem. 279 (13): 12551–9. doi:10.1074/jbc.M313365200. PMID   14729908.
• Casteel DE, Boss GR, Pilz RB (2005). "Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif". J. Biol. Chem. 280 (46): 38211–8. doi: 10.1074/jbc.M507021200 . PMID   16166082.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Antl M, von Brühl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S, Schlossmann J (2007). "IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation". Blood. 109 (2): 552–9. doi: 10.1182/blood-2005-10-026294 . PMID   16990611.

External links

• MRVI1 human gene location in the UCSC Genome Browser .
• MRVI1 human gene details in the UCSC Genome Browser .