MS15203

Last updated

MS15203
MS15203 structure.png
Identifiers
  • 5-(2-methylprop-2-enoylamino)benzene-1,3-dicarboxylic acid
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
Formula C12H11NO5
Molar mass 249.222 g·mol−1
3D model (JSmol)
  • CC(=C)C(=O)NC1=CC(=CC(=C1)C(=O)O)C(=O)O
  • InChI=1S/C12H11NO5/c1-6(2)10(14)13-9-4-7(11(15)16)3-8(5-9)12(17)18/h3-5H,1H2,2H3,(H,13,14)(H,15,16)(H,17,18)
  • Key:NVOBVSWSDYFEMR-UHFFFAOYSA-N

MS15203 (5-Methacrylamidoisophthalic acid) is an experimental drug which acts as a selective agonist for the neuropeptide receptor GPR171. In studies on mice it increases food intake and has analgesic effects, but shows sex-selective activity with greater effects in male mice than in female mice. [1] [2] [3]

References

  1. Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, et al. (May 2016). "Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake". Science Signaling. 9 (430): ra55. doi:10.1126/scisignal.aac8035. PMC   5150984 . PMID   27245612.
  2. Ram A, Edwards T, McCarty A, Afrose L, McDermott MV, Bobeck EN (2021). "GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice". Frontiers in Pain Research. 2 695396. Lausanne, Switzerland. doi: 10.3389/fpain.2021.695396 . PMC   8915562 . PMID   35295419.
  3. McDermott MV, Ram A, Mattoon MT, Haderlie EE, Raddatz MC, Thomason MK, et al. (March 2023). "A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice". Pharmacology, Biochemistry, and Behavior. 224 173543. doi:10.1016/j.pbb.2023.173543. PMC   11472835 . PMID   36933620.