MT1B

MT1B
Identifiers
Aliases	MT1B , MT1, MT1Q, MTP, metallothionein 1B, MT-IB, MT-1B
External IDs	OMIM: 156349; HomoloGene: 48385; GeneCards: MT1B; OMA:MT1B - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q13 Start 56,651,886 bp [1] End 56,653,204 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum appendix mucosa of esophagus left uterine tube urinary bladder human musculoskeletal system skeletal muscle islet of Langerhans muscle of leg n/a More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding metal ion binding Cellular component cytoplasm perinuclear region of cytoplasm nucleus Biological process negative regulation of growth cellular response to zinc ion cellular zinc ion homeostasis detoxification of copper ion cellular response to cadmium ion cellular response to copper ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4490 n/a Ensembl ENSG00000169688 n/a UniProt P07438 n/a RefSeq (mRNA) NM_005947 n/a RefSeq (protein) NP_005938 n/a Location (UCSC) Chr 16: 56.65 – 56.65 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Metallothionein-1B is a protein that in humans is encoded by the MT1B gene. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000169688 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi: 10.1073/pnas.81.17.5494 . PMC   391732 . PMID   6089206.
4. Heguy A, West A, Richards RI, Karin M (Dec 1986). "Structure and tissue-specific expression of the human metallothionein IB gene". Mol Cell Biol. 6 (6): 2149–57. doi:10.1128/MCB.6.6.2149. PMC   367755 . PMID   3785191.
5. "Entrez Gene: MT1B metallothionein 1B".

Further reading

• Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis". BMC Genomics. 8: 26. doi: 10.1186/1471-2164-8-26 . PMC   1796866 . PMID   17244347.
• Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID   15747776. S2CID   14394243.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID   12539042. S2CID   26145639.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID   2286373.